Molecular Genetics of Childhood Cancer: Implications for Pathogenesis, Diagnosis, and Treatment

Research into the genetic aspects of cancer has led to improved diagnostic tests that can also provide prognostic information. Most cancers have a genetic basis, usually the activation of an oncogene or the inactivation of a tumor suppressor gene. Some cancers are caused by the abnormal fusion of tw...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1997-07, Vol.100 (1), p.101-108
Main Authors: Rubnitz, Jeffrey E, Crist, William M
Format: Article
Language:English
Subjects:
Acute Disease
Age Factors
Biological and medical sciences
Cancer in children
Child
Child, Preschool
Childhood cancer
General aspects
Genes, Tumor Suppressor
Genetic aspects
Humans
Infant
Leukemia, Myeloid - diagnosis
Leukemia, Myeloid - etiology
Leukemia, Myeloid - genetics
Leukemia, Myeloid - therapy
Lymphoma - diagnosis
Lymphoma - etiology
Lymphoma - genetics
Lymphoma - therapy
Medical sciences
Molecular genetics
Neoplasms - diagnosis
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - therapy
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Prognosis
Translocation, Genetic
Tumors
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Summary:Research into the genetic aspects of cancer has led to improved diagnostic tests that can also provide prognostic information. Most cancers have a genetic basis, usually the activation of an oncogene or the inactivation of a tumor suppressor gene. Some cancers are caused by the abnormal fusion of two genes. Karyotyping has been used in the past to identify the genetic abnormality in most cancers. However, it is being replaced by fluorescence in situ hybridization, Southern blot analysis and the reverse transcriptase-polymerase chain reaction.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.100.1.101