Ion mobility spectrometry of halothane, enflurane, and isoflurane anesthetics in air and respired gases

Three common gaseous anesthetics, halothane, enflurane, and isoflurane, were characterized by using ion mobility spectrometry (IMS)/mass spectrometry, and the dependence of product ion distributions on temperature and concentration was evaluated. At 40 degrees C and 500 ppb, negative ion mobility sp...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 1989-05, Vol.61 (10), p.1093-1099
Main Authors: Eiceman, G. A, Shoff, D. B, Harden, C. S, Snyder, A. P, Martinez, P. M, Fleischer, M. E, Watkins, M. L
Format: Article
Language:English
Subjects:
Air - analysis
Analysis
Anesthetics - analysis
Biological and medical sciences
Enflurane - analysis
General pharmacology
Halothane - analysis
Humans
Isoflurane - analysis
Mass Spectrometry - methods
Medical sciences
Pharmacology. Drug treatments
Respiration
Temperature
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Summary:Three common gaseous anesthetics, halothane, enflurane, and isoflurane, were characterized by using ion mobility spectrometry (IMS)/mass spectrometry, and the dependence of product ion distributions on temperature and concentration was evaluated. At 40 degrees C and 500 ppb, negative ion mobility spectra in air largely consisted of monomer or dimer adducts with Br- or Cl- formed through dissociative electron capture of molecular neutrals. With increased temperature or decreased vapor concentrations, declustering and dissociation of product ions became pronounced. Ion-molecule reactions in the drift region of the IMS were evident as distortions in peak shape in the mass-resolved mobility spectra and in variable reduced mobilities for the same ions. A portable hand-held IMS was used for convenient, real-time detection of enflurane in respired gases following a controlled inhalation episode.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac00185a010