Syncytia formation in HIV-1 infected cells is associated with an increase in cellular oleic acid

Infection of cells with the human immunodeficiency virus type-1 (HIV-1) usually results in the formation of giant multinuclear cells (syncytia) [(1986) Nature 322, 470-474; (1986) Nature 322, 725-728; (1985) Hum. Pathol. 18, 760-765; (1987) Arm. Neurol. 21, 490-496]. The appearance of syncytia is as...

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Bibliographic Details
Published in:FEBS letters 1989-07, Vol.250 (2), p.241-244
Main Authors: Apostolov, K., Barker, W., Galpin, S.A., Habib, N.A., Wood, C.B., Kinchington, D.
Format: Article
Language:English
Subjects:
AIDS/HIV
Antiviral therapy
Biological and medical sciences
Cell Line
Cell Membrane - metabolism
Cytopathogenic Effect, Viral
Fatty acid
Fatty Acids - analysis
Fundamental and applied biological sciences. Psychology
HIV
HIV Antigens - analysis
HIV-1 - drug effects
HIV-1 - immunology
HIV-1 - physiology
human immunodeficiency virus 1
Interferon Type I - pharmacology
Microbiology
Oleic Acid
Oleic Acids - metabolism
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Stearic Acids - pharmacology
Syncytia
Virology
Zidovudine - pharmacology
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Summary:Infection of cells with the human immunodeficiency virus type-1 (HIV-1) usually results in the formation of giant multinuclear cells (syncytia) [(1986) Nature 322, 470-474; (1986) Nature 322, 725-728; (1985) Hum. Pathol. 18, 760-765; (1987) Arm. Neurol. 21, 490-496]. The appearance of syncytia is associated with an increase in the monounsaturated oleic acid content. This report describes experiments which compare the activity of known antiviral agents with that of saturated fatty acid derivatives in inhibiting oleic acid and syncytia formation. A concept is introduced which proposes that infection of cells with the human immunodeficiency virus causes a rise in cellular oleic acid which leads to increased membrane fluidity.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)80730-6