Porcine gastric mucosa associated lymphoid tissue (MALT): stimulation by colonization with the gastric bacterial pathogen, Helicobacter pylori

The presence and features of mucosa associated lymphoid tissue (MALT), analogous to Peyer's pathches, in the cardia of the lesser curvature of the porcine stomach are described. The gastric mucosa associated lymphoid tissue (gastric-MALT) is histologically distinct from gastric inflammation ass...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 1997-05, Vol.56 (1), p.119-131
Main Authors: Green, Wendy Barnes, Eaton, Kathryn, Krakowka, Steven
Format: Article
Language:English
Subjects:
Animals
AXENIE
CERDO
ESTOMAC
ESTOMAGO
EXENCION DE PATOGENOS ESPECIFICOS
Female
Gastric Mucosa - immunology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Germ-Free Life
Gnotobiology
Helicobacter Infections - immunology
Helicobacter Infections - pathology
Helicobacter Infections - veterinary
HELICOBACTER PYLORI
Helicobacter pylori - growth & development
Helicobacter pylori - immunology
Humans
IMMUNE RESPONSE
LINFOCITOS
LYMPHOCYTE
Lymphocyte Activation
LYMPHOCYTES
Lymphoid Tissue - immunology
Lymphoid Tissue - microbiology
Lymphoid Tissue - pathology
MALT
Mucosal immunity
Organ Specificity - immunology
Pig
PORCIN
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
SPECIFIC PATHOGEN FREE STATE
STOMACH
SWINE
Swine Diseases - immunology
Swine Diseases - microbiology
Swine Diseases - pathology
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Description
Summary:The presence and features of mucosa associated lymphoid tissue (MALT), analogous to Peyer's pathches, in the cardia of the lesser curvature of the porcine stomach are described. The gastric mucosa associated lymphoid tissue (gastric-MALT) is histologically distinct from gastric inflammation associated with colonization by normal gastric microflora and experimental bacterial colonization with a human gastric bacterial pathogen, Helicobacter pylori. The gastric-MALT consists of well-demarcated encapsulated and organized lymphoid tissue, intimately associated with overlying gastric epithelium, centered below the muscularis mucosae and drained by efferent lymphatics. Gastric-MALT was identified in all piglets studied including microbially sterile uninfected gnotobiotes; these structures were enlarged with age and local (gastric) antigenic stimulation. Significant ( P < 0.05) expansion of the gastric-MALT occurred in H. pylori-infected gnotobiotic piglets. These distinct morphologic features and location in the cardia suggest that lymphoid elements in the gastric-MALT are involved in gastric antigen processing and regional lymphoid maturation, differentiation and proliferation in the stomach.
ISSN:0165-2427
1873-2534
DOI:10.1016/S0165-2427(96)05736-4