Effects of an endotoxin challenge on growth performance, carcass accretion rates, and serum hormone and metabolite concentrations in control pigs and those treated with recombinant porcine somatotropin

• Published in: Journal of animal science 1997-07, Vol.75 (7), p.1784-1790
• Main Authors: Evock-Clover, C.M. (Livestock and Poultry Sciences Institute, ARS, USDA, Beltsville, MD.), Myers, M.J, Steele, N.C
• Format: Article
• Language: English
• Subjects: ADIPOSE TISSUES; Animal productions; Animals; AREA; ASHES; AZUCAR EN SANGRE; BACKFAT; BARDIERE; BAZO; Biological and medical sciences; Blood Glucose - analysis; Blood Glucose - metabolism; BLOOD SERUM; BLOOD SUGAR; Body Composition - drug effects; Body Composition - physiology; BODY FAT; Body Mass Index; BODY PROTEIN; BODY TEMPERATURE; Body Temperature - drug effects; Body Temperature - physiology; BODY WEIGHT; Body Weight - drug effects; Body Weight - physiology; CENDRE; CENIZA; CERDO; COEUR; CORAZON; EFFICACITE ALIMENTAIRE; EFICIENCIA DE CONVERSION DEL PIENSO; Endotoxins - pharmacology; ESCHERICHIA COLI; FACTEUR DE CROISSANCE IGF; FACTOR DE CRECIMIENTO IGF; FAT THICKNESS; FEED CONVERSION EFFICIENCY; FEED INTAKE; FOIE; Fundamental and applied biological sciences. Psychology; GAIN DE POIDS; GANANCIA DE PESO; GLANDE THYMUS; GLANDULA DEL TIMO; Growth Hormone - blood; Growth Hormone - pharmacology; HEART; HIGADO; Hogs; Hormones; INGESTION DE PIENSOS; INJECTION; Injections, Intramuscular - veterinary; INSULIN; Insulin - blood; INSULIN-LIKE GROWTH FACTOR; Insulin-Like Growth Factor I - analysis; Insulin-Like Growth Factor I - metabolism; INSULINA; INSULINE; INTRAVENOUS INJECTION; INYECCION; KIDNEYS; Lipid Metabolism; LIPOPOLISACARIDOS; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDES; Lipopolysaccharides - pharmacology; LIVER; LIVEWEIGHT GAIN; Male; Meat - standards; MUSCLE; MUSCLES; MUSCULOS; Nitrogen - blood; Nutrition; PESO; PESO CORPORAL; Physical growth; POIDS; POIDS CORPOREL; PORCIN; PRISE ALIMENTAIRE (ANIMAUX); PROTEINAS; PROTEINE; PROTEINS; Proteins - metabolism; RATE; Recombinant Proteins - pharmacology; REIN; RINONES; SERUM SANGUIN; SOMATOTROPIN; SOMATOTROPINA; SOMATOTROPINE; SPLEEN; SUCRE DU SANG; SUERO SANGUINEO; SWINE; Swine - blood; Swine - growth & development; Swine - metabolism; TEJIDO ADIPOSO; TEMPERATURA DEL CUERPO; TEMPERATURE CORPORELLE; Terrestrial animal productions; THYMUS GLAND; TISSU ADIPEUX; TOCINO DORSAL; UREA; Urea - blood; UREE; Vertebrates; WEIGHT; WEIGHT GAIN
• ISSN: 0021-8812; 1525-3163; 0021-8812
• DOI: 10.2527/1997.7571784x

Barrows were restrictively fed starting at 20 kg BW to determine the effects of endotoxin on growth performance of control and somatotropin-treated pigs. The following treatments were used: (1) daily i.m. vehicle injection until 55 kg BW; (2) daily i.m. injections of 100 microgram of recombinant porcine somatotropin (pST)/kg BW, until 55 kg; (3) i.v. saline injections for 7 d consecutively starting at 60 kg BW; (4) i.v. injections of 1 microgram of bacterial lipopolysaccharide (LPS)/kg BW for 7 d starting at 60 kg BW; and (5) the combined LPS + pST treatment, with pST injections from 20 kg through the 7 d of LPS treatment. Pigs evaluated for LPS effects were fed to 60 kg anticipating a weight loss. Pigs were bled at 0800 and 1100 at 55 kg and on d 7 of LPS treatment. Rectal temperatures were taken on d 7. Treatment with pST increased ADG by 13 to 20% and improved feed:gain by 17 to 23% before LPS treatment. During the 7 d of LPS injections, ADG and feed:gain did not differ, although feed efficiency was impaired and variable. Rectal temperatures at 1100 were progressively increased: control LPS LPS-pST (P .01). Protein accretion was improved 27% by pST treatment, and lipid accretion was decreased 45% before LPS. Lipid stores decreased (P .01) after LPS treatment in the pST-treated pigs. Lipopolysaccharide treatment and (or) decreased feed intake reduced the hyperinsulinemia and hyperglycemia (P .01 ) associated with pST treatment. These results indicate that LPS induced a simulated septicemia and that the effects were not negated by pST treatment. The observed hyperthermia was additive, possibly due to increased lean body mass induced by pST combined with the pyrogenic effect of LPS