Biologically active peptides of casein and lactotransferrin implicated in platelet function

Casein and other milk proteins in maternal colostrum and milk, the earliest food of the newborn, should not only be considered as a nutritional supply but also as a source of biologically active peptides. Some of them isolated from casein and lactotransferrin were active on platelet function. They i...

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Bibliographic Details
Published in:Journal of dairy research 1989-01, Vol.56 (3), p.351-355
Main Authors: Fiat, Anne-Marie, Levy-Toledano, Sylviane, Caen, Jacques P., Jollès, Pierre
Format: Article
Language:English
Subjects:
Animals
blood platelets
Blood Platelets - drug effects
Blood Platelets - physiology
Caseins - analysis
Caseins - physiology
Cattle
clotting
Female
kappa-casein
Lactoferrin - analysis
Lactoferrin - physiology
Lactoglobulins - analysis
lactotransferrin
Oligopeptides - pharmacology
Original Articles
peptides
platelets
siderophilins
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Summary:Casein and other milk proteins in maternal colostrum and milk, the earliest food of the newborn, should not only be considered as a nutritional supply but also as a source of biologically active peptides. Some of them isolated from casein and lactotransferrin were active on platelet function. They inhibited both aggregation of ADP-treated platelets and binding of [125I] fibrinogen to ADP-treated platelets. Their behaviour was compared to that of fibrinogen peptides possessing similar effects: once more similarities between the milk and blood-clotting phenomena could be observed.
ISSN:0022-0299
1469-7629
DOI:10.1017/S002202990002879X