Chronic postnatal hypoxia increases the numbers of cortical neurons

Premature infants have been shown to undergo prolonged periods of sublethal hypoxia. There is considerable evidence to link these hypoxic events with neurodevelopmental disorders. As an animal model for this clinical problem, rats were raised from the third day of life in a chamber where the O 2 lev...

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Bibliographic Details
Published in:Brain research 1997-06, Vol.760 (1), p.17-21
Main Authors: Stewart, William B, Ment, Laura R, Schwartz, Michael
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Count
Cell death
Cerebral cortex
Cerebral Cortex - pathology
Corticogenesis
Development
Disease Models, Animal
Hypoxia
Hypoxia - pathology
Rats
Time Factors
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Summary:Premature infants have been shown to undergo prolonged periods of sublethal hypoxia. There is considerable evidence to link these hypoxic events with neurodevelopmental disorders. As an animal model for this clinical problem, rats were raised from the third day of life in a chamber where the O 2 level was 9.5%. After 30 days of hypoxia the rats were sacrificed and their brains processed for determination of the number of cortical neurons. This work was performed to test the hypothesis that chronic hypoxia would result in increased cortical cell death. The hypoxic rats had lower body and brain weights as well as decreased cortical volumes. However, hypoxic rats had increased neuronal density and significantly more cortical neurons than controls ( P
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)00271-0