Strongyloides stercoralis: is there a canonical migratory route through the host?

It is generally accepted that the skin-penetrating larvae of Strongyloides stercoralis travel from the skin to the intestinal habitat of the adult stage by an obligatory migratory route that includes the blood, lungs, trachea, and upper gastrointestinal tract in sequence (the pulmonary route). It is...

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Bibliographic Details
Published in:The Journal of parasitology 1989-10, Vol.75 (5), p.740-749
Main Authors: Schad, G.A. (University of Pennsylvania, Philadelphia, PA), Aikens, L.M, Smith, G
Format: Article
Language:English
Subjects:
Animal and plant ecology
Animal, plant and microbial ecology
Animals
Autoecology
Autoradiography
Biological and medical sciences
CHIEN
DOGS
Duodenum
Duodenum - parasitology
Fundamental and applied biological sciences. Psychology
Host-Parasite Interactions
Ileum - parasitology
Infections
Intestines
Larva - physiology
LARVAE
Larval development
LARVAS
LARVE
Life Cycle and Development
Lung - parasitology
Lungs
Lymph Nodes - parasitology
Mesentery
MIGRACION
MIGRATION
Muscles - parasitology
Nematode larvae
Parasitology
PERRO
Protozoa. Invertebrata
Selenomethionine - metabolism
Skin - parasitology
Specific Pathogen-Free Organisms
STRONGYLOIDES
Strongyloides - physiology
Strongyloidiasis - parasitology
TECHNIQUE DES TRACEURS
TECNICAS DE AISLAMIENTO DE ISOTOPOS
TRACER TECHNIQUES
Trachea
Trachea - parasitology
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Summary:It is generally accepted that the skin-penetrating larvae of Strongyloides stercoralis travel from the skin to the intestinal habitat of the adult stage by an obligatory migratory route that includes the blood, lungs, trachea, and upper gastrointestinal tract in sequence (the pulmonary route). It is assumed, furthermore, that following autoinfective invasion of the bowel wall, S. stercoralis larvae follow this same route to return to the small intestine where they mature. We reexamined the parasite's migratory behavior using a canine isolate of S. stercoralis, specific-pathogen-free pups, radiolabeled larvae, and compressed tissue autoradiography. Compartmental analysis of the number of larvae found in the organ sets examined revealed no reason to reject the simple idea that the pulmonary route was just one of several possible pathways to the duodenum. This was true whether the larvae began their journey in the subcutaneous tissue of the inguinal area or in the distal part of the ileum. Direct sampling of the larvae traversing the trachea indicated that the number of larvae reaching the duodenum by way of the presumptive pulmonary route was insufficient to account for the estimated absolute number actually found there.
ISSN:0022-3395
1937-2345
DOI:10.2307/3283059