Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine

• Published in: International journal of cardiology 1997-08, Vol.61 (1), p.21-29
• Main Authors: Serebruany, Victor L, Schlossberg, Matthew L, Edenbaum, Lisa R, Herzog, William R, Gurbel, Paul A
• Format: Article
• Language: English
• Subjects: Animal model; Animals; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Calcium Channel Blockers - administration & dosage; Calcium Channel Blockers - pharmacology; Calcium Channel Blockers - therapeutic use; Diltiazem; Diltiazem - administration & dosage; Diltiazem - pharmacology; Diltiazem - therapeutic use; Disease Models, Animal; Eicosanoids - blood; Endothelin-1 - blood; Female; Fibronectins - blood; Hemostasis; Hemostasis - drug effects; Infusions, Intra-Arterial; Medical sciences; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - drug therapy; Pharmacology. Drug treatments; Swine
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/S0167-5273(97)00111-3

Controversy currently exists regarding the use of diltiazem in the treatment of acute myocardial infarction (AMI), due to conflicting results from clinical trials and animal studies. The purpose of this project was to evaluate the changes in the hemostatic profile during AMI following low dose intracoronary diltiazem infusion. Fourteen Yorkshire swine underwent thoracotomy and 50 min LAD occlusion, followed by 3 h of reperfusion. The first group (n=8) received 2.5 mg of diltiazem intracoronary at a rate of 5.6 μgkgmin−1 at the onset of reperfusion. The second group (n=6) received 0.9% saline intracoronary at the onset of reperfusion and served as the control. The dynamics of plasma antithrombin-III (AT-III), Protein C, total Protein S, fibronectin, endothelin-1 (ET-1), and the stable metabolites of thromboxane (TxB2) and prostacyclin (6-keto- PGF1a) were determined at baseline, then twice during occlusion and finally three times during reperfusion. Diltiazem infusion resulted in diminished ET-1 (34.5%), fibronectin (23.2%), and TxB2 (35.6%); and elevated Protein C (29.3%) when compared with controls. We conclude that intracoronary diltiazem favorably influences hemostasis during AMI in swine. The cardioprotective effects of diltiazem during AMI may be related to the improved hemostatic profile and the reduced incidence of thrombotic complications in such patients.