The Effect of Tenidap on Cytokines, Acute-Phase Proteins, and Virus Load in Human Immunodeficiency Virus (HIV)-Infected Patients: Correlation between Plasma HIV-1 RNA and Proinflammatory Cytokine Levels

• Published in: The Journal of infectious diseases 1997-09, Vol.176 (3), p.807-810
• Main Authors: Dezube, Bruce J., Lederman, Michael M., Chapman, Beryl, Georges, Daniel L., Dogon, Alex L., Mudido, Phillipa, Reis-Lishing, Joann, Cheng, Shu-Lin, Silberman, Sandra L., Crumpacker, Clyde S.
• Format: Article
• Language: English
• Subjects: Acute phase proteins; Acute-Phase Proteins - analysis; Adult; AIDS/HIV; Anti-HIV Agents - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Blood plasma; C-Reactive Protein - analysis; CD4 Lymphocyte Count; Concise Communications; Cross-Over Studies; Cytokines; Cytokines - blood; Double-Blind Method; HIV; HIV 1; HIV Core Protein p24 - blood; HIV Infections - blood; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - isolation & purification; Humans; Indoles - therapeutic use; Interleukin-1 - blood; Interleukin-6 - blood; Medical sciences; Pharmacology. Drug treatments; Placebos; Rheumatoid arthritis; RNA; RNA, Viral - blood; Serum Amyloid A Protein - analysis; Tumor Necrosis Factor-alpha - analysis; Tumor necrosis factors; Viral Load; Viruses
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/517308

Proinflammatory cytokines may be important in the pathogenesis of human immunodeficiency virus type 1 (HIV-1) disease. Tenidap decreases interleukin (IL)-6, IL-1, and tumor necrosis factor (TNF) production by peripheral blood mononuclear cells and decreases IL-6 plasma levels in rheumatoid arthritis patients. In this randomized double-blind study, 43 HIV-1-infected patients received tenidap (120 mg) or placebo daily for 6 weeks and then crossed over to the alternative therapy for an additional 6 weeks. Mean entry CD4 cell count was 140/µL. Analyses were performed on cytokines, acute-phase proteins, virus load, and CD4 cell counts. With the exception of small differences in plasma TNF levels, tenidap had no significant effect on these indices. Significant correlations of plasma IL-6 and TNF levels with HIV-1 RNA were noted. Six patients discontinued tenidap due to rash. The effects of tenidap in HIV-1 infection contrast to results in arthritis patients, in whom tenidap decreased plasma levels of IL-6 and acute-phase proteins.