A low blood lymphocyte count is associated with an expansion of activated cytotoxic lymphocytes in patients with B-cell chronic lymphocytic leukaemia

: In order to determine the relationships between CD2+ lymphocyte subpopulations and tumour mass, the immunophenotype of natural killer (NK) cells and T lymphocyte subsets was studied in 56 B‐chronic lymphocytic leukaemia (B‐CLL) patients and 38 healthy subjects. The patients were classified accordi...

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Bibliographic Details
Published in:European journal of haematology 1997-08, Vol.59 (2), p.89-99
Main Authors: Martín, Alfredo Prieto, Martín, Eduardo Reyes, Arriagada, Flavio Carrión, Hernandez-Fuentes, Maria del Puerto, Vilaplana, Joan Cháfer, García-Suárez, Julio, Soto, Melchor Alvarez-Mon
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS/HIV
Antigens, CD - analysis
B-chronic lymphocytic leukaemia
Biological and medical sciences
blood lymphocyte count
CD4-CD8 Ratio
cytotoxic T lymphocytes
Female
helper lymphocytes
Hematologic and hematopoietic diseases
Humans
Immunophenotyping
Leukemia, Lymphocytic, Chronic, B-Cell - immunology
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocyte Activation
Lymphocyte Subsets
Male
Medical sciences
Middle Aged
NK cells
T-Lymphocytes, Cytotoxic - cytology
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Summary:: In order to determine the relationships between CD2+ lymphocyte subpopulations and tumour mass, the immunophenotype of natural killer (NK) cells and T lymphocyte subsets was studied in 56 B‐chronic lymphocytic leukaemia (B‐CLL) patients and 38 healthy subjects. The patients were classified according to their blood lymphocyte count (BLC). Forty patients had BLC30×109/l (high BLC, larger tumour mass). The percentage of CD3– CD56+ cells, as well as of CD8+, CD8+CD45RO+ and CD3+CD57+ T subsets in low BLC patients, were higher than those found in high BLC patients. Conversely, the percentages of CD3+HLA DR+, CD4+ and CD4+CD45RO+ lymphocytes were higher in high BLC patients than in low BLC patients. The CD4/CD8 ratio was decreased in low BLC patients while it was increased in high BLC patients and a significant positive correlation was found between their CD4/CD8 ratio and their BLC. We conclude that in low BLC B‐CLL patients there is a decreased percentage of activated helper lymphocytes and an increased percentage of NK cells and activated cytotoxic T lymphocytes. These results suggest a role for NK cells, and helper and cytotoxic T lymphocytes in the control of tumour burden in B‐CLL patients.
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.1997.tb00731.x