Osteoclast-like giant cell tumour of the pancreas presenting as a pseudocyst-like lesion

A 57-year-old male patient presented with a cystic lesion in the tail of the pancreas, which was considered to be a pseudocyst. He was treated by cystojejunostomy but one year later a tumour was found to have invaded the stomach and jejunum. This was an osteoclast-like giant cell tumour containing a...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1997-09, Vol.431 (3), p.215-218
Main Authors: OEHLER, U, JÜRS, M, KLÖPPEL, G, HELPAP, B
Format: Article
Language:English
Subjects:
Antigens, Nuclear
Biological and medical sciences
Biomarkers, Tumor - analysis
Diagnosis, Differential
Fatal Outcome
Gastroenterology. Liver. Pancreas. Abdomen
Giant Cell Tumors - pathology
Giant Cell Tumors - surgery
Humans
Immunohistochemistry
Jejunum - pathology
Keratins - analysis
Ki-67 Antigen
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Nuclear Proteins - analysis
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Pancreatic Pseudocyst - pathology
Pancreatic Pseudocyst - surgery
Tumors
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Summary:A 57-year-old male patient presented with a cystic lesion in the tail of the pancreas, which was considered to be a pseudocyst. He was treated by cystojejunostomy but one year later a tumour was found to have invaded the stomach and jejunum. This was an osteoclast-like giant cell tumour containing a small area of typical ductal adenocarcinoma. Immunohistochemical staining revealed that the pleomorphic tumour cells were positive for cytokeratin, epithelial membrane antigen, vimentin and the proliferation marker MIB-1. The osteoclast-like giant cells and some small histiocytic cells stained for leukocyte common antigen and histiocytic markers and were negative for MIB-1. At autopsy, tumour rests were found in the pancreas but there were no metastases. Osteoclast-like giant cell tumours of the pancreas may present as cystic lesions and should be included in the differential diagnosis of pseudocysts.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050091