Reversal of dyskinesis by increased end diastolic segment length in ischaemic-reperfused myocardium

Persistent dyskinesis is universally observed after reperfusion of a severely ischaemic segment. Although inotropic stimulation shows a latent contractile reserve, it is not known whether this reserve can be recruited by increasing end diastolic segment length (local length-tension relation). To inv...

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Bibliographic Details
Published in:Cardiovascular research 1989-09, Vol.23 (9), p.810-820
Main Authors: VINTEN-JOHANSEN, J, CARROLL, PAUL J, JOHNSTON, WILLIAM E, LITTLE, WILLIAM C, CHIANTELLA, VIRGINIA, JULIAN, J STEVE, CORDELL, A ROBERT
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure
Cardiology. Vascular system
Cardiopulmonary Bypass
Coronary Disease - etiology
Coronary Disease - physiopathology
Coronary heart disease
coronary occlusion
Coronary Vessels - surgery
Dogs
dyskinetic myocardium
Heart
Ligation
Medical sciences
Myocardial Contraction
Myocardial Reperfusion
pressure-segment length relations
reperfusion
Time Factors
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Summary:Persistent dyskinesis is universally observed after reperfusion of a severely ischaemic segment. Although inotropic stimulation shows a latent contractile reserve, it is not known whether this reserve can be recruited by increasing end diastolic segment length (local length-tension relation). To investigate this, six anaesthetised open chest dogs were placed on right heart bypass to increase end diastolic segment length independently of mean arterial pressure. Instantaneous left ventricular pressure-segment length relations and fractional systolic shortening were determined by sono-micrometry in the centre of the region perfused by the left anterior descending coronary artery during sequential increases in end diastolic segment length. Measurements were made before occlusion of the left anterior descending coronary artery, during 1 h of occlusion, and after 2 h of reperfusion. Before ischaemia, segmental shortening increased from 11.0(SEM 1.6)% to 23.5(1.5)% (p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/23.9.810