Glia, neurons, and axon pathfinding during optic chiasm development

The importance of vision in the behavior of animals, from invertebrates to primates, has led to a good deal of interest in how projection neurons in the retina make specific connections with targets in the brain. Recent research has focused on the cellular interactions occurring between retinal gang...

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Bibliographic Details
Published in:Current opinion in neurobiology 1997-10, Vol.7 (5), p.647-653
Main Authors: Mason, Carol A, Sretavan, David W
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Humans
Neuroglia - physiology
Neurons - physiology
Optic Chiasm - cytology
Optic Chiasm - embryology
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Summary:The importance of vision in the behavior of animals, from invertebrates to primates, has led to a good deal of interest in how projection neurons in the retina make specific connections with targets in the brain. Recent research has focused on the cellular interactions occurring between retinal ganglion cell (RGC) axons and specific glial and neuronal populations in the embryonic brain during formation of the mouse optic chiasm. These interactions appear to be involved both in determining the position of the optic chiasm on the ventral diencephalon (presumptive hypothalamus) and in ipsilateral and contralateral RGC axon pathfinding, developmental events fundamental to binocular vision in the adult animal.
ISSN:0959-4388
1873-6882
DOI:10.1016/S0959-4388(97)80084-0