Vertical transmission of cytomegalovirus, most probably by breast milk, to an infant with Wiskott-Aldrich syndrome with fatal outcome

A 4-month-old boy with prenatally diagnosed Wiskott-Aldrich syndrome became ill with a severe cytomegalovirus (CMV) infection, the outcome of which was fatal. The parents had isolated the infant from other children and adhered to standards of hygiene in order to avoid CMV infection because their fir...

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Bibliographic Details
Published in:European journal of pediatrics 1997-11, Vol.156 (11), p.854-855
Main Authors: RICHTER, D, HAMPL, W, POHLANDT, F
Format: Article
Language:English
Subjects:
AIDS/HIV
Biological and medical sciences
Breast Feeding
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - transmission
Fatal Outcome
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infant
Infectious Disease Transmission, Vertical
Male
Medical sciences
Opportunistic Infections - complications
Opportunistic Infections - transmission
Wiskott-Aldrich Syndrome - complications
Wiskott-Aldrich Syndrome - immunology
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Description
Summary:A 4-month-old boy with prenatally diagnosed Wiskott-Aldrich syndrome became ill with a severe cytomegalovirus (CMV) infection, the outcome of which was fatal. The parents had isolated the infant from other children and adhered to standards of hygiene in order to avoid CMV infection because their first child had died of Wiskott-Aldrich syndrome and CMV infection. The mother breast-fed her child although she was CMV IgG positive. The source of infection was most probably breast milk, which contained CMV at the time the infant developed the generalized CMV infection. In infants with immunodeficiency syndromes, CMV infection may have a fatal outcome. Since the virus can be transmitted by breast milk, the advantages and disadvantages of breast-feeding should, therefore, be weighed in newborn infants with an immunodeficiency syndrome whose mother is a CMV carrier.
ISSN:0340-6199
1432-1076
DOI:10.1007/s004310050729