Fetuin expression in the dorsal root ganglia and trigeminal ganglia of perinatal rats

Fetuin, a fetal plasma glycoprotein, has been shown previously to be present in sub‐populations of neurons in the developing central and peripheral nervous system. To gain a more complete description of the time course of the appearance of fetuin during neurogenesis we have examined fetuin immunorea...

Full description

Saved in:
Bibliographic Details
Published in:International journal of developmental neuroscience 1997-10, Vol.15 (6), p.717-727
Main Authors: Kitchener, P.D., Dziegielewska, K.M., Knott, G.W., Miller, J.M., Nawratil, P., Potter, A.E., Saunders, N.R.
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - biosynthesis
Animals
dorsal root ganglion
Embryonic and Fetal Development - physiology
fetuin
Ganglia, Spinal - embryology
Ganglia, Spinal - growth & development
Ganglia, Spinal - metabolism
glycoprotein
Immunohistochemistry
In Situ Hybridization
Nerve Tissue Proteins - biosynthesis
plasma protein
Rats
Rats, Wistar
RNA, Messenger - biosynthesis
Trigeminal Ganglion - embryology
Trigeminal Ganglion - growth & development
Trigeminal Ganglion - metabolism
trigeminalganglion
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fetuin, a fetal plasma glycoprotein, has been shown previously to be present in sub‐populations of neurons in the developing central and peripheral nervous system. To gain a more complete description of the time course of the appearance of fetuin during neurogenesis we have examined fetuin immunoreactivity, and the presence of fetuin mRNA, in the developing rat trigeminal and dorsal root ganglia. Fetuin immunoreactivity and its mRNA were first seen at embryonic day 15 in the trigeminal ganglia, and at embryonic day 16 in dorsal root ganglia. In both trigeminal and dorsal root ganglion, fetuin appeared to be present up until around the time of birth, and then again between postnatal days 3 and 16. The results suggest that fetuin first appears at around the time that ganglion cell axons reach their central targets, which is also approximately when the cell‐death period begins. The proportion of ganglion neurons that were fetuin immunoreactive at different ages was inversely related to the amount of cell death that is known to occur in these populations, thus it seems that fetuin is more likely to be associated not with dying cells, but with those that survive the cell‐death period.
ISSN:0736-5748
1873-474X
DOI:10.1016/S0736-5748(97)00030-0