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Urinary growth hormone: a screening test for growth hormone sufficiency
OBJECTIVES The majority of short statured children referred for serum GH testing prove to be GH sufficient. The purpose of our study was to evaluate urinary growth hormone (uGH) as a screening test for GH sufficiency. PATIENTS We studied (i) short statured children previously diagnosed as GH suffici...
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| Published in: | Clinical endocrinology (Oxford) 1997-10, Vol.47 (4), p.447-454 |
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| Main Authors: | , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4362-459049b5d9927288b38b08ca997e33e9efbbf6139f12854708ea5678068868f13 |
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| container_issue | 4 |
| container_start_page | 447 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 47 |
| creator | Butt, Debra A. Sochett, Etienne B. |
| description | OBJECTIVES
The majority of short statured children referred for serum GH testing prove to be GH sufficient. The purpose of our study was to evaluate urinary growth hormone (uGH) as a screening test for GH sufficiency.
PATIENTS
We studied (i) short statured children previously diagnosed as GH sufficient (n = 44) or GH deficient (n = 41) (peak serum GH ≥8 μg/l or 2.3 ng/m2). When this and other cut‐offs were applied to the test group, we found consistency between the observed and predicted numbers of GH sufficient and deficient subjects.
CONCLUSIONS
We conclude that urinary GH is a useful test for the diagnosis of GH sufficiency as defined by serum criteria and can be used to reduce significantly the number of serum stimulation tests. |
| doi_str_mv | 10.1046/j.1365-2265.1997.2821086.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79467978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79467978</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4362-459049b5d9927288b38b08ca997e33e9efbbf6139f12854708ea5678068868f13</originalsourceid><addsrcrecordid>eNqVkEtPGzEUhS3UClLgJyCNUNXdTK_fNgskFEFohagqXkvLY2xwmMxQOxHJv--MMsqiu66sq3Pu8bkfQqcYKgxMfJ9XmApeEiJ4hbWWFVEEgxLVeg9NdtInNAEKUIIQ7AB9yXkOAFyB3Ef7mgFjjE7Q7CHF1qZN8ZK6j-Vr8dqlRdf6s8IW2SXv29i-FEufl0Xo0j-mIq9CiC761m2O0Odgm-yPx_cQPVxd3k-vy5tfsx_Ti5vSMSpIybgGpmv-rDWRRKmaqhqUs_0RnlKvfajrIDDVARPFmQTlLRdSgVBKqIDpIfq2zX1P3Z9V38ssYna-aWzru1U2UjMhtVS98WxrdKnLOflg3lNc9JcaDGagaOZmQGUGVGagaEaKZt0vn4y_rOqFf96tjth6_euo2-xsE5JtXcw7G1FMcTmUPd_aPmLjN_9RwEwvb_uhDyi3ATEv_XoXYNObEZJKbp5uZ4ZR-H13_fPKPNK_yG-bwQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79467978</pqid></control><display><type>article</type><title>Urinary growth hormone: a screening test for growth hormone sufficiency</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Butt, Debra A. ; Sochett, Etienne B.</creator><creatorcontrib>Butt, Debra A. ; Sochett, Etienne B.</creatorcontrib><description>OBJECTIVES
The majority of short statured children referred for serum GH testing prove to be GH sufficient. The purpose of our study was to evaluate urinary growth hormone (uGH) as a screening test for GH sufficiency.
PATIENTS
We studied (i) short statured children previously diagnosed as GH sufficient (n = 44) or GH deficient (n = 41) (peak serum GH ≥8 μg/l or <8 μg/l, respectively); (ii) short children undergoing serum GH stimulation tests (n = 23, test group); (iii) normal statured children (n = 45, control group).
DESIGN
Three separate overnight urine collections were obtained in all groups. GH injections in GH deficient subjects were discontinued 4 days prior to urine collection.
MEASUREMENTS
uGH concentrations were measured using a chemiluminescence immunoassay. Overnight uGH was expressed in several ways (overnight excretion and overnight excretion corrected for body surface area, time and creatinine). Receiver operator curves (ROC) were constructed from the data obtained in the GH sufficient and deficient subjects. Sensitivity and specificity were then determined for various urinary cut‐offs. These cutoffs were validated in turn in the test group by comparison of the predicted with the observed GH status.
RESULTS
The GH deficient group had the lowest GH output with respect to overnight uGH, overnight uGH/m2, overnight uGH/h and overnight uGH/creatinine when compared with the GH sufficient and control groups (P = 0.0001). Overnight uGH/m2 data gave the greatest area under the ROC curve. At 100% specificity (no GH deficient subjects), it had the highest sensitivity, 63.6% (49.2–78.0% CI) at a cut‐off of 2.3 ng/m2 (63.6% of GH sufficient subjects had uGH levels >2.3 ng/m2). When this and other cut‐offs were applied to the test group, we found consistency between the observed and predicted numbers of GH sufficient and deficient subjects.
CONCLUSIONS
We conclude that urinary GH is a useful test for the diagnosis of GH sufficiency as defined by serum criteria and can be used to reduce significantly the number of serum stimulation tests.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1046/j.1365-2265.1997.2821086.x</identifier><identifier>PMID: 9404443</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Analysis of Variance ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Functional investigation of endocrine glands and genital system ; Growth Disorders - diagnosis ; Growth Disorders - urine ; Growth Hormone - deficiency ; Growth Hormone - urine ; Humans ; Immunoassay ; Immunoenzyme Techniques ; Investigative techniques, diagnostic techniques (general aspects) ; Luminescent Measurements ; Male ; Medical sciences ; Predictive Value of Tests ; Regression Analysis ; ROC Curve ; Sensitivity and Specificity</subject><ispartof>Clinical endocrinology (Oxford), 1997-10, Vol.47 (4), p.447-454</ispartof><rights>Blackwell Science Ltd, Oxford</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4362-459049b5d9927288b38b08ca997e33e9efbbf6139f12854708ea5678068868f13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2848571$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9404443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butt, Debra A.</creatorcontrib><creatorcontrib>Sochett, Etienne B.</creatorcontrib><title>Urinary growth hormone: a screening test for growth hormone sufficiency</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clinical Endocrinology</addtitle><description>OBJECTIVES
The majority of short statured children referred for serum GH testing prove to be GH sufficient. The purpose of our study was to evaluate urinary growth hormone (uGH) as a screening test for GH sufficiency.
PATIENTS
We studied (i) short statured children previously diagnosed as GH sufficient (n = 44) or GH deficient (n = 41) (peak serum GH ≥8 μg/l or <8 μg/l, respectively); (ii) short children undergoing serum GH stimulation tests (n = 23, test group); (iii) normal statured children (n = 45, control group).
DESIGN
Three separate overnight urine collections were obtained in all groups. GH injections in GH deficient subjects were discontinued 4 days prior to urine collection.
MEASUREMENTS
uGH concentrations were measured using a chemiluminescence immunoassay. Overnight uGH was expressed in several ways (overnight excretion and overnight excretion corrected for body surface area, time and creatinine). Receiver operator curves (ROC) were constructed from the data obtained in the GH sufficient and deficient subjects. Sensitivity and specificity were then determined for various urinary cut‐offs. These cutoffs were validated in turn in the test group by comparison of the predicted with the observed GH status.
RESULTS
The GH deficient group had the lowest GH output with respect to overnight uGH, overnight uGH/m2, overnight uGH/h and overnight uGH/creatinine when compared with the GH sufficient and control groups (P = 0.0001). Overnight uGH/m2 data gave the greatest area under the ROC curve. At 100% specificity (no GH deficient subjects), it had the highest sensitivity, 63.6% (49.2–78.0% CI) at a cut‐off of 2.3 ng/m2 (63.6% of GH sufficient subjects had uGH levels >2.3 ng/m2). When this and other cut‐offs were applied to the test group, we found consistency between the observed and predicted numbers of GH sufficient and deficient subjects.
CONCLUSIONS
We conclude that urinary GH is a useful test for the diagnosis of GH sufficiency as defined by serum criteria and can be used to reduce significantly the number of serum stimulation tests.</description><subject>Adolescent</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Functional investigation of endocrine glands and genital system</subject><subject>Growth Disorders - diagnosis</subject><subject>Growth Disorders - urine</subject><subject>Growth Hormone - deficiency</subject><subject>Growth Hormone - urine</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunoenzyme Techniques</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Luminescent Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Predictive Value of Tests</subject><subject>Regression Analysis</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqVkEtPGzEUhS3UClLgJyCNUNXdTK_fNgskFEFohagqXkvLY2xwmMxQOxHJv--MMsqiu66sq3Pu8bkfQqcYKgxMfJ9XmApeEiJ4hbWWFVEEgxLVeg9NdtInNAEKUIIQ7AB9yXkOAFyB3Ef7mgFjjE7Q7CHF1qZN8ZK6j-Vr8dqlRdf6s8IW2SXv29i-FEufl0Xo0j-mIq9CiC761m2O0Odgm-yPx_cQPVxd3k-vy5tfsx_Ti5vSMSpIybgGpmv-rDWRRKmaqhqUs_0RnlKvfajrIDDVARPFmQTlLRdSgVBKqIDpIfq2zX1P3Z9V38ssYna-aWzru1U2UjMhtVS98WxrdKnLOflg3lNc9JcaDGagaOZmQGUGVGagaEaKZt0vn4y_rOqFf96tjth6_euo2-xsE5JtXcw7G1FMcTmUPd_aPmLjN_9RwEwvb_uhDyi3ATEv_XoXYNObEZJKbp5uZ4ZR-H13_fPKPNK_yG-bwQ</recordid><startdate>199710</startdate><enddate>199710</enddate><creator>Butt, Debra A.</creator><creator>Sochett, Etienne B.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199710</creationdate><title>Urinary growth hormone: a screening test for growth hormone sufficiency</title><author>Butt, Debra A. ; Sochett, Etienne B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4362-459049b5d9927288b38b08ca997e33e9efbbf6139f12854708ea5678068868f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Functional investigation of endocrine glands and genital system</topic><topic>Growth Disorders - diagnosis</topic><topic>Growth Disorders - urine</topic><topic>Growth Hormone - deficiency</topic><topic>Growth Hormone - urine</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunoenzyme Techniques</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Luminescent Measurements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Predictive Value of Tests</topic><topic>Regression Analysis</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butt, Debra A.</creatorcontrib><creatorcontrib>Sochett, Etienne B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butt, Debra A.</au><au>Sochett, Etienne B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary growth hormone: a screening test for growth hormone sufficiency</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clinical Endocrinology</addtitle><date>1997-10</date><risdate>1997</risdate><volume>47</volume><issue>4</issue><spage>447</spage><epage>454</epage><pages>447-454</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>OBJECTIVES
The majority of short statured children referred for serum GH testing prove to be GH sufficient. The purpose of our study was to evaluate urinary growth hormone (uGH) as a screening test for GH sufficiency.
PATIENTS
We studied (i) short statured children previously diagnosed as GH sufficient (n = 44) or GH deficient (n = 41) (peak serum GH ≥8 μg/l or <8 μg/l, respectively); (ii) short children undergoing serum GH stimulation tests (n = 23, test group); (iii) normal statured children (n = 45, control group).
DESIGN
Three separate overnight urine collections were obtained in all groups. GH injections in GH deficient subjects were discontinued 4 days prior to urine collection.
MEASUREMENTS
uGH concentrations were measured using a chemiluminescence immunoassay. Overnight uGH was expressed in several ways (overnight excretion and overnight excretion corrected for body surface area, time and creatinine). Receiver operator curves (ROC) were constructed from the data obtained in the GH sufficient and deficient subjects. Sensitivity and specificity were then determined for various urinary cut‐offs. These cutoffs were validated in turn in the test group by comparison of the predicted with the observed GH status.
RESULTS
The GH deficient group had the lowest GH output with respect to overnight uGH, overnight uGH/m2, overnight uGH/h and overnight uGH/creatinine when compared with the GH sufficient and control groups (P = 0.0001). Overnight uGH/m2 data gave the greatest area under the ROC curve. At 100% specificity (no GH deficient subjects), it had the highest sensitivity, 63.6% (49.2–78.0% CI) at a cut‐off of 2.3 ng/m2 (63.6% of GH sufficient subjects had uGH levels >2.3 ng/m2). When this and other cut‐offs were applied to the test group, we found consistency between the observed and predicted numbers of GH sufficient and deficient subjects.
CONCLUSIONS
We conclude that urinary GH is a useful test for the diagnosis of GH sufficiency as defined by serum criteria and can be used to reduce significantly the number of serum stimulation tests.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9404443</pmid><doi>10.1046/j.1365-2265.1997.2821086.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 1997-10, Vol.47 (4), p.447-454 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Analysis of Variance Biological and medical sciences Child Child, Preschool Female Functional investigation of endocrine glands and genital system Growth Disorders - diagnosis Growth Disorders - urine Growth Hormone - deficiency Growth Hormone - urine Humans Immunoassay Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Luminescent Measurements Male Medical sciences Predictive Value of Tests Regression Analysis ROC Curve Sensitivity and Specificity |
| title | Urinary growth hormone: a screening test for growth hormone sufficiency |
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