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Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants
The comparative mechanisms and relative rates of nitrogen dioxide (NO 2 ⋅), thiyl (RS ⋅) and sulphonyl (RSO 2 ⋅) radical scavenging by the carotenoid antioxidants lycopene, lutein, zeaxanthin, astaxanthin and canthaxanthin have been determined by pulse radiolysis. All the carotenoids under study rea...
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Published in: | FEBS letters 1997-11, Vol.418 (1), p.91-97 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The comparative mechanisms and relative rates of nitrogen dioxide (NO
2
⋅), thiyl (RS
⋅) and sulphonyl (RSO
2
⋅) radical scavenging by the carotenoid antioxidants lycopene, lutein, zeaxanthin, astaxanthin and canthaxanthin have been determined by pulse radiolysis. All the carotenoids under study react with the NO
2
⋅ radical via electron transfer to generate the carotenoid radical cation (Car
⋅+). In marked contrast the glutathione and 2-mercaptoethanol thiyl radicals react via a radical addition process to generate carotenoid-thiyl radical adducts [RS-Car]
⋅. The RSO
2
⋅ radical undergoes both radical addition, [RSO
2-Car]
⋅ and electron abstraction, Car
⋅+. Both carotenoid adduct radicals and radical cations decay bimolecularly. Absolute rate constants for radical scavenging were in the order of ∼10
7–10
9 M
−1 s
−1 and follow the sequence HO(CH
2)
2S
⋅>RSO
2
⋅>GS
⋅>NO
2
⋅. Although there were some discernible trends in carotenoid reactivity for individual radicals, rate constants varied by no greater than a factor of 2.5. The mechanism and rate of scavenging is strongly dependent on the nature of the oxidising radical species but much less dependent on the carotenoid structure. |
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ISSN: | 0014-5793 1873-3468 |
DOI: | 10.1016/S0014-5793(97)01355-0 |