Apolipoprotein B and AI distributions in the United States, 1988–1991: results of the National Health and Nutrition Examination Survey III (NHANES III)

• Published in: Clinical chemistry (Baltimore, Md.) Md.), 1997-12, Vol.43 (12), p.2364-2378
• Main Authors: Bachorik, Paul S, Lovejoy, Kathleen L, Carroll, Margaret D, Johnson, Clifford L
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Analytical, structural and metabolic biochemistry; Apolipoprotein A-I - blood; Apolipoproteins B - blood; Biological and medical sciences; Black or African American; Black People; Child; Child, Preschool; Fasting; Female; Fundamental and applied biological sciences. Psychology; Humans; Lipoproteins, myelin; Male; Mexican Americans; Middle Aged; Population Surveillance; Proteins; Sex Factors; United States; White People
• ISSN: 0009-9147; 1530-8561
• DOI: 10.1093/clinchem/43.12.2364

Serum apolipoproteins (apo) B and AI were measured in a probability sample of the noninstitutionalized US civilian population, ages > or = 4 years, which included non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans. Apo B concentrations were the same in males and females, lower in black males than in other males, low in childhood (approximately 0.80 g/L) and increasing to approximately 1.2 g/L in adults, and higher in younger women on hormones. Apo AI was higher in females than males, higher in blacks than in others, remained constant from childhood to adulthood (approximately 1.35 g/L) in males, but increased with age (approximately 1.30 g/L to approximately 1.55 g/L) in females, and was higher in women taking hormones. These are the first national probability estimates of apo B and apo AI in the US and are referable to the WHO-IFCC First International Reference Materials for apo AI and B.