Detection of EBV RNA (EBER-1 and EBER-2) in Malaria Lymph Nodes by In Situ Hybridization

Acute Plasmodium falciparum malaria in African children allows expansion of latent Epstein-Barr virus infection, leading to colonization of lymph nodes by virus-infected lymphoblasts in 60% of cases as demonstrated by in situ hybridization for the detection of EBER-1 and EBER-2 RNA. This probably ar...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1997, Vol.41(11), pp.891-894
Main Authors: Facer, Christine, Khan, George
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Burkitt Lymphoma - etiology
Burkitt Lymphoma - pathology
Burkitt Lymphoma - virology
Cameroon
Child, Preschool
EBV
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - isolation & purification
Hodgkin Disease - pathology
Hodgkin Disease - virology
Human viral diseases
Humans
In Situ Hybridization
Infant
Infectious diseases
Lymph nodes
Lymph Nodes - pathology
Lymph Nodes - virology
Malaria
Malaria, Falciparum - complications
Male
Medical sciences
Oligonucleotide Probes
Plasmodium falciparum - physiology
RNA, Viral - analysis
Tonsillectomy
Tropical medicine
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Acute Plasmodium falciparum malaria in African children allows expansion of latent Epstein-Barr virus infection, leading to colonization of lymph nodes by virus-infected lymphoblasts in 60% of cases as demonstrated by in situ hybridization for the detection of EBER-1 and EBER-2 RNA. This probably arises against a background of malaria-induced immunosuppression to EBV and concurrent lymphoid activation. The relevance of the results to the pathogenesis of African endemic Burkitt's lymphoma is discussed.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1997.tb01946.x