A role for immunogenic dna in the pathogenesis of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antibodies to a diverse array of nuclear antigens (antinuclear antibodies). Among these antinuclear antibodies, those specific for DNA (anti-DNA antibodies) are highly characteristic of SLE, serv...

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Bibliographic Details
Published in:Arthritis and rheumatism 1990-02, Vol.33 (2), p.153-159
Main Authors: Pisetsky, David S., Grudier, Jane P., Gilkeson, Gary S.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Antinuclear - analysis
Biological and medical sciences
Complement System Proteins - analysis
DNA - immunology
DNA, Bacterial - immunology
DNA, Single-Stranded - immunology
Escherichia coli
Humans
Lupus Erythematosus, Systemic - etiology
Lupus Erythematosus, Systemic - immunology
Medical sciences
Mice
Mice, Inbred C57BL
Receptors, Complement - analysis
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
T-Lymphocytes - immunology
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Summary:Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antibodies to a diverse array of nuclear antigens (antinuclear antibodies). Among these antinuclear antibodies, those specific for DNA (anti-DNA antibodies) are highly characteristic of SLE, serving as markers of diagnostic and prognostic significance. Because of the central role of anti-DNA antibodies in the immunopathogenesis of SLE, the expression of these antibodies has been intensively investigated both in humans and in murine models of this diseases. To unify the divergent notions, a set of hypotheses will be presented to explain the expression of anti-DNA antibodies in both normal and autoimmune conditions. Salient features of anti-DNA antibodies will be reviewed in order to provide a context for this model of anti-DNA antibody involvement in SLE.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780330202