Neovascularization in atherectomy specimens from patients with unstable angina: Implications for pathogenesis of unstable angina

Although neovascularization has been noted in atherosclerotic plaque, the presence of neovascularization has not been correlated with clinical syndromes. This study examined the relation between neovascularization in atherosclerotic plaque removed during directional coronary atherectomy and clinical...

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Bibliographic Details
Published in:The American heart journal 1998, Vol.135 (1), p.10-14
Main Authors: Tenaglia, Alan N., Peters, Kevin G., Sketch, Jr, Michael H., Annex, Brian H.
Format: Article
Language:English
Subjects:
Angina Pectoris - etiology
Angina Pectoris - pathology
Angina Pectoris - surgery
Angina, Unstable - etiology
Angina, Unstable - pathology
Angina, Unstable - surgery
Atherectomy, Coronary
Biological and medical sciences
Cardiology. Vascular system
Coronary Artery Disease - complications
Coronary Artery Disease - pathology
Coronary Artery Disease - surgery
Coronary heart disease
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Neovascularization, Pathologic - complications
Recurrence
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Summary:Although neovascularization has been noted in atherosclerotic plaque, the presence of neovascularization has not been correlated with clinical syndromes. This study examined the relation between neovascularization in atherosclerotic plaque removed during directional coronary atherectomy and clinical status in 28 patients. Neovascularization was determined by immunohistochemistry with endothelial cell–specific monoclonal antibodies and was found in nine (50%) of 18 specimens from patients with unstable angina and in only one (10%) of 10 specimens from patients with stable angina ( p < 0.05). There was no significant relation between neovascularization and other clinical factors (age, sex, race, hypertension, diabetes, tobacco use, hypercholesterolemia, positive family history of coronary artery disease, history of myocardial infarction, or stenosis severity). These results suggest that neovascularization may play a role in the pathogenesis of unstable angina. (Am Heart J 1998;135:10-4.)
ISSN:0002-8703
1097-6744
DOI:10.1016/S0002-8703(98)70336-9