Control of breathing during sleep assessed by proportional assist ventilation

• Published in: Journal of applied physiology (1985) 1998-01, Vol.84 (1), p.3-12
• Main Authors: Meza, S, Giannouli, E, Younes, M
• Format: Article
• Language: English
• Subjects: Adult; Air Pressure; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Down-Regulation - physiology; Emergency and intensive respiratory care; Female; Humans; Intensive care medicine; Male; Medical sciences; Middle Aged; Polysomnography; Positive-Pressure Respiration - instrumentation; Respiratory Mechanics - physiology; Sleep - physiology; Sleep, REM - physiology
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1998.84.1.3

Respiratory Investigation Unit, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3A 1R8 Meza, S., E. Giannouli, and M. Younes. Control of breathing during sleep assessed by proportional assist ventilation. J. Appl. Physiol. 84(1): 3-12, 1998. We used proportional assist ventilation (PAV) to evaluate the sources of respiratory drive during sleep. PAV increases the slope of the relation between tidal volume (V T ) and respiratory muscle pressure output (Pmus). We reasoned that if respiratory drive is dominated by chemical factors, progressive increase of PAV gain should result in only a small increase in V T because Pmus would be downregulated substantially as a result of small decreases in P CO 2 . In the presence of substantial nonchemical sources of drive [believed to be the case in rapid-eye-movement (REM) sleep] PAV should result in a substantial increase in minute ventilation and reduction in P CO 2 as the output related to the chemically insensitive drive source is amplified severalfold. Twelve normal subjects underwent polysomnography while connected to a PAV ventilator. Continuous positive air pressure (5.2 ± 2.0 cmH 2 O) was administered to stabilize the upper airway. PAV was increased in 2-min steps from 0 to 20, 40, 60, 80, and 90% of the subject's elastance and resistance. V T , respiratory rate, minute ventilation, and end-tidal CO 2 pressure were measured at the different levels, and Pmus was calculated. Observations were obtained in stage 2 sleep ( n  = 12), slow-wave sleep ( n  = 11), and REM sleep ( n  = 7). In all cases, Pmus was substantially downregulated with increase in assist so that the increase in V T , although significant ( P