Localization of the Brain Lesion Affects the Lateralization of T‐Lymphocyte Dependent Cutaneous Inflammation. Evidence for an Immunoregulatory Role of the Right Frontal Cortex–Putamen Region

We have previously demonstrated that brain lesions caused by stroke led to the lateralization of T‐cell dependent inflammation. The purpose of this study was to assess the impact of localization of the brain lesion on lateralization of immune responsiveness. The delayed‐type hypersensitivity (DTH) r...

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Bibliographic Details
Published in:Scandinavian journal of immunology 1998-01, Vol.47 (1), p.30-36
Main Authors: Tarkowski, E, Jensen, C, Ekholm, S, Ekelund, P, Blomstrand, C, Tarkowski, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brain Diseases - etiology
Brain Diseases - immunology
Cerebrovascular Disorders - complications
Cerebrovascular Disorders - immunology
Dermatitis, Allergic Contact - immunology
Epitopes - immunology
Female
Frontal Lobe - immunology
Humans
Hypersensitivity, Delayed - immunology
Male
Middle Aged
Prospective Studies
Putamen - immunology
T-Lymphocytes - immunology
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Summary:We have previously demonstrated that brain lesions caused by stroke led to the lateralization of T‐cell dependent inflammation. The purpose of this study was to assess the impact of localization of the brain lesion on lateralization of immune responsiveness. The delayed‐type hypersensitivity (DTH) reaction was used as an in vivo measure of antigen specific T‐lymphocyte reactivity. All stroke patients were examined with computed scan tomography (CT) of the brain to ascertain the localization and extent of the brain lesion. Patients with right‐sided brain lesions displayed significantly larger (P = 0.008) DTH responses on the paretic side compared to the contralateral side. Detailed analysis of the localization of the brain lesion revealed that infarcts encompassing frontal lobe–putamen led to significantly larger (P = 0.007) DTH responses on the paretic side compared to the contralateral side. Localization of the brain lesion affects the lateralization of DTH, supporting an asymmetrical modulation of the immune response. In addition, our study points to the frontal cortex–putamen as a putative brain centre regulating the magnitude of immune responses.
ISSN:0300-9475
1365-3083
DOI:10.1046/j.1365-3083.1998.00243.x