Apolipoprotein screening in Australian children: feasibility and the effect of age, sex, and ethnicity

Objectives (i) To evaluate the feasibility of detecting adverse lipid profiles in schoolchildren by measuring capillary dried blood spot apolipoprotein levels, and (ii) to assess the effect of age, sex and ethnicity on apolipoprotein levels. Design We measured capillary dried blood spot apolipoprote...

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Bibliographic Details
Published in:Medical journal of Australia 1998-01, Vol.168 (2), p.61-64
Main Authors: Lynch, Judith F, Marshall, Michelle D, Wang, Xing L, Wilcken, David E L
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Asia - ethnology
Australia
Biological and medical sciences
Child
Child, Preschool
Cholesterol - blood
Disorders of blood lipids. Hyperlipoproteinemia
Ethnic Groups
Feasibility Studies
Female
Humans
India - ethnology
Male
Medical sciences
Metabolic diseases
Predictive Value of Tests
Risk Factors
Sex Factors
Tropical medicine
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Summary:Objectives (i) To evaluate the feasibility of detecting adverse lipid profiles in schoolchildren by measuring capillary dried blood spot apolipoprotein levels, and (ii) to assess the effect of age, sex and ethnicity on apolipoprotein levels. Design We measured capillary dried blood spot apolipoproteins B and A‐l (apo B and apo A‐l); assessed levels in relation to age, sex and ethnicity; and recalled children with elevated levels for a full lipid profile measurement. Participants and setting 6992 children (3501 boys and 3491 girls), aged 5‐13 years, from schools in eastern Sydney, 1991‐1995. Main outcome measures Capillary blood levels of apolipoproteins B and A‐l, and serum total cholesterol level. Results Of the 6951 children who provided an adequate fingerprick blood sample, we recalled 1465 children (21.1%) (640 boys [43.7%] and 825 girls [56.3%]) with elevated apo B levels and/or apo B: apo A‐l ratios for further testing, either by us or by their family doctor (overall estimated compliance rate up to 70%). Among the 458 children who returned to us, there was a 90% positive predictive value for a total cholesterol level of over 4.5 mmol/L in those with both elevated apo B levels and high apo B: apo A‐l ratios. Girls had higher apo B levels and apo B: apo A‐l ratios than boys (P
ISSN:0025-729X
1326-5377
DOI:10.5694/j.1326-5377.1998.tb126712.x