In Vitro Replication Kinetics of Human Immunodeficiency Virus Type 1 (HIV-1) Variants in Relation to Virus Load in Long-Term Survivors of HIV-1 Infection

In 7 long-term survivors (LTS) and 8 progressors, all carrying solely non-syncytium-inducing variants, a possible correlation between in vitro virus replicative capacity, virus load, and clinical course of human immunodeficiency virus type 1 (HIV-1) infection was analyzed. Late in infection, 3 LTS a...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-03, Vol.177 (3), p.600-610
Main Authors: Blaak, Hetty, Brouwer, Margreet, Ran, Leonie J., de Wolf, Frank, Schuitemaker, Hanneke
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - virology
AIDS
AIDS/HIV
Amino Acid Sequence
Biological and medical sciences
Cytopathogenic Effect, Viral
Disease Progression
Fundamental and applied biological sciences. Psychology
Genes, nef
Genetic Variation
HIV
HIV 1
HIV Infections - virology
HIV-1 - physiology
Humans
Infections
Kinetics
Longitudinal Studies
Major Articles
Microbiology
Molecular Sequence Data
Netherlands
Phenotypes
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
RNA
Sequence Homology, Amino Acid
Survivors
T lymphocytes
Viral Load
Virology
Virus Cultivation
Virus Replication
Viruses
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Summary:In 7 long-term survivors (LTS) and 8 progressors, all carrying solely non-syncytium-inducing variants, a possible correlation between in vitro virus replicative capacity, virus load, and clinical course of human immunodeficiency virus type 1 (HIV-1) infection was analyzed. Late in infection, 3 LTS and 7 progressors had a high virus load, which coincided with the presence of rapid-replicating viruses. In contrast to progressors, LTS maintained relatively high and stable CD4 T cell counts. Four LTS persistently had relatively slow-replicating viruses and a low virus load, even after 6.6–9 years of seropositive follow-up. All virus isolates from 1 of these LTS had a 4-aa deletion in nef. These results suggest a correlation between the in vitro replicative capacity of non-syncytium-inducing HIV-1 variants and virus load. The presence of HIV-1 variants with relatively low replicative capacity throughout infection may have contributed to the beneficial clinical course in half of the LTS in this study.
ISSN:0022-1899
1537-6613
DOI:10.1086/514219