A comparison of the haemodynamic effects of propofol and isoflurane in pregnant ewes

The purpose of this study was to compare the effects of inhaled isoflurane and a constant infusion of propofol on maternal haemodynamics and uterine arterial and umbilical venous flows in pregnant ewes. Late term pregnant ewes (n = 5) were randomly assigned to receive either inhaled isoflurane or an...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 1998-02, Vol.21 (1), p.69-73
Main Authors: Gaynor, J S, Wertz, E M, Alvis, M, Turner, A S
Format: Article
Language:English
Subjects:
Animals
Blood Flow Velocity - drug effects
Blood Pressure - drug effects
Female
Heart Rate - drug effects
Hemodynamics - drug effects
Infusions, Intravenous
Isoflurane - administration & dosage
Isoflurane - pharmacology
Pregnancy
Pregnancy, Animal - physiology
Propofol - administration & dosage
Propofol - pharmacology
Pulmonary Artery - drug effects
Pulmonary Artery - physiology
Sheep
Umbilical Veins - drug effects
Umbilical Veins - physiology
Uterus - blood supply
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Summary:The purpose of this study was to compare the effects of inhaled isoflurane and a constant infusion of propofol on maternal haemodynamics and uterine arterial and umbilical venous flows in pregnant ewes. Late term pregnant ewes (n = 5) were randomly assigned to receive either inhaled isoflurane or an intravenous infusion of propofol for 1 h, each on separate occasions. Maternal systemic arterial, right atrial and pulmonary arterial blood pressures, cardiac index, systemic vascular resistance index, stroke volume index, heart rate, and uterine arterial and umbilical venous flows were determined over the 1 h period of each treatment. Data were analysed using an univariate analysis of variance for repeated measures performed on the ranks of the data. Propofol anaesthetized ewes had significantly higher heart rate (P = 0.0040), mean arterial pressure (P = 0.0003) and cardiac index (P = 0.0475) compared to isoflurane anaesthetized ewes. There were no significant differences in uterine arterial flows, umbilical venous flows, or other measured variables. Continuous propofol infusions maintain maternal haemodynamics at significantly higher levels than does inhaled isoflurane, while uterine arterial and umbilical venous flows do not differ significantly.
ISSN:0140-7783
1365-2885
DOI:10.1046/j.1365-2885.1998.00110.x