Fetal intracardiac echogenic foci: does it matter which ventricle?

We sought to determine whether an association exists between the location of intracardiac echogenic foci and fetal aneuploidy or structural cardiac lesions. A search of the English language literature since 1980 revealed nine studies reporting location of intracardiac echogenic foci, fetal chromosom...

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Bibliographic Details
Published in:Journal of ultrasound in medicine 1998-03, Vol.17 (3), p.141-144
Main Authors: Wax, J. R, Philput, C
Format: Article
Language:English
Subjects:
Aneuploidy
Biological and medical sciences
Cardiovascular system
Chromosomes
Echocardiography
Female
Fetal Diseases - diagnostic imaging
Fetal monitoring
Gynecology. Andrology. Obstetrics
Heart Defects, Congenital - diagnostic imaging
Heart Defects, Congenital - genetics
Heart Ventricles - diagnostic imaging
Humans
Management. Prenatal diagnosis
Medical problems
Medical sciences
Muscle
Pregnancy
Pregnancy. Fetus. Placenta
Ultrasonography, Prenatal
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Summary:We sought to determine whether an association exists between the location of intracardiac echogenic foci and fetal aneuploidy or structural cardiac lesions. A search of the English language literature since 1980 revealed nine studies reporting location of intracardiac echogenic foci, fetal chromosomal abnormalities, and cardiac anomalies. Aneuploidy was noted in 10 of 217 fetuses with left ventricular and in one of 18 with right ventricular intracardiac echogenic foci. Three of 11 fetuses with biventricular intracardiac echogenic foci were aneuploid, which is significantly more frequently than when intracardiac echogenic foci were present in either ventricle alone (P = 0.02). There were nine cases of trisomy 21, four of trisomy 13, and one of trisomy 18. Structural cardiac lesions were recognized in eight of 217 fetuses with left ventricular foci, two of 18 with right ventricular foci, and one of 11 with biventricular intracardiac echogenic foci (P = 0.16). Biventricular intracardiac echogenic foci are more frequently associated with fetal aneuploidy but not structural lesions, as compared to isolated left or right ventricular intracardiac echogenic foci.
ISSN:0278-4297
1550-9613
DOI:10.7863/jum.1998.17.3.141