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Exercise-Induced Oxidative Stress in Patients During Thallium Stress Testing
Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is grea...
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Published in: | The American journal of the medical sciences 1998-03, Vol.315 (3), p.185-187 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is greater among those with than those without exerciseinduced myocardial ischemia.
Methods: The effect of physical exercise stress testing on plasma malonaldehyde (MDA) levels was compared between patients with (Group A, N = 8) and without (Group B) exer~ ise-i!lduced myocardial ischemia by thallium ImagIng.
Analysis: Two-way ANOVA was used to compare plasma MDA levels pre- and post-exercise and paired t-test comparisons were conducted for percent MDA changes between Group A and Group B patients.
Results: Two-way ANOVA revealed a significant (P = 0.002) directional difference in response to exercise between the groups' mean plasma MDA levels (Group A increased by 46 ± 12.7 percent, Group B decreased by 16.8 ± 4.6 percent).
Conclusions: Differences in exercise-induced lipid peroxidation between patients with and without thallium documentation of myocar~ ial ischemia have important implications In the development of clinical markers of coronary artery disease and further research related to atherogenesis. |
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ISSN: | 0002-9629 1538-2990 |
DOI: | 10.1016/S0002-9629(15)40303-9 |