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Exercise-Induced Oxidative Stress in Patients During Thallium Stress Testing

Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is grea...

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Bibliographic Details
Published in:The American journal of the medical sciences 1998-03, Vol.315 (3), p.185-187
Main Authors: Kleinman, Michael T., Alexander Leaf, David, Yusin, Mark, Gallik, Donna
Format: Article
Language:English
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Summary:Free radical injury is implicated ~n the ~athogenesis of coronary artery disease, ~ncludmg atherogenesis and reperfusionlinJUry. Strenuous physical exercise can cause oxidative stress by several mechanisms, includingreperfusionlinjury. We hypothesize that exercise- induced lipid peroxidation is greater among those with than those without exerciseinduced myocardial ischemia. Methods: The effect of physical exercise stress testing on plasma malonaldehyde (MDA) levels was compared between patients with (Group A, N = 8) and without (Group B) exer~ ise-i!lduced myocardial ischemia by thallium ImagIng. Analysis: Two-way ANOVA was used to compare plasma MDA levels pre- and post-exercise and paired t-test comparisons were conducted for percent MDA changes between Group A and Group B patients. Results: Two-way ANOVA revealed a significant (P = 0.002) directional difference in response to exercise between the groups' mean plasma MDA levels (Group A increased by 46 ± 12.7 percent, Group B decreased by 16.8 ± 4.6 percent). Conclusions: Differences in exercise-induced lipid peroxidation between patients with and without thallium documentation of myocar~ ial ischemia have important implications In the development of clinical markers of coronary artery disease and further research related to atherogenesis.
ISSN:0002-9629
1538-2990
DOI:10.1016/S0002-9629(15)40303-9