A metabolic approach to simulating the dynamics of C-14, H-3 and S-35 in sheep tissues

The results of a study in which groups of sheep were given single oral administrations of 14C, 3H and 35S and then slaughtered over a period of 1 year are reported. The experimental data were used to investigate the potential of metabolically based models for describing the transfer of the three rad...

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Bibliographic Details
Published in:Radiation and environmental biophysics 1998-02, Vol.36 (4), p.243-250
Main Authors: Crout, N M, Mayes, R W, Beresford, N A, Lamb, C S, Howard, B J
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Bone and Bones - metabolism
Carbon Radioisotopes - administration & dosage
Carbon Radioisotopes - pharmacokinetics
Female
Models, Biological
Muscle, Skeletal - metabolism
Sheep - metabolism
Sulfur Radioisotopes - administration & dosage
Sulfur Radioisotopes - pharmacokinetics
Time Factors
Tissue Distribution
Tritium - administration & dosage
Tritium - pharmacokinetics
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Summary:The results of a study in which groups of sheep were given single oral administrations of 14C, 3H and 35S and then slaughtered over a period of 1 year are reported. The experimental data were used to investigate the potential of metabolically based models for describing the transfer of the three radionuclides to sheep tissues. The structure of these models is based upon a simplified understanding of the transfer of the macro-elements C, H and S by processes such as respiration and protein synthesis/degradation. A consequence of this approach is that the three models have many common parameters. The models reproduced the general trends of the observations, accounting for 74%, 66%, and 58% of the observed variation in the 14C, 3H and 35S data, respectively, suggesting that they may provide a useful alternative approach to modelling the transfer of these radionuclides. The models presented are limited to the particular experimental situation for which they were developed, and further experimental work would be required to extend them. However, such metabolically based models have great potential: for example, they should be able to account for the influence of dietary intake, physiological status or the form of the radionuclide in the animals diet (e.g. tritiated water or organically bound tritium).
ISSN:0301-634X
1432-2099
DOI:10.1007/s004110050078