effect of biogenic amines and their analogs on carbohydrate metabolism in the fat body of the cockroach Blaberus discoidalis

Several biogenic amines and their analogs were examined for stimulatory effects on glycogen phosphorylase activity and trehalose biosynthesis in fat body of the cockroach, Blaberus discoidalis. Octopamine and synephrine were the most potent activators of fat body phosphorylase; 10 muM octopamine bei...

Full description

Saved in:
Bibliographic Details
Published in:General and comparative endocrinology 1998-04, Vol.110 (1), p.88-95
Main Authors: Park, J.H, Keeley, L.L
Format: Article
Language:English
Subjects:
Amidines - pharmacology
animal physiology
Animals
arthropods
Biogenic Amines - pharmacology
Carbohydrate Metabolism
Cockroaches - drug effects
Cockroaches - metabolism
entomology
Fat Body - drug effects
Fat Body - enzymology
Fat Body - metabolism
Octopamine - agonists
Octopamine - pharmacology
Phosphorylases - metabolism
Structure-Activity Relationship
Synephrine - pharmacology
Trehalose - biosynthesis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several biogenic amines and their analogs were examined for stimulatory effects on glycogen phosphorylase activity and trehalose biosynthesis in fat body of the cockroach, Blaberus discoidalis. Octopamine and synephrine were the most potent activators of fat body phosphorylase; 10 muM octopamine being nearly as effective as the hypertrehalosemic hormone (HTH). Epinephrine, norepinephrine, and tyramine produced intermediate effects, whereas dopamine, 5-hydroxytryptamine, and melatonin had no effect. The fat body octopamine receptors appeared to be pharmacologically related to vertebrate alpha-adrenergic receptors and belonged to the Octopamine1 class receptor. In contrast to previous reports, synephrine also induced both phosphorylase activation and hypertrehalosemia as effectively as octopamine. Demethylchlordimeform, a formamidine insecticide structurally similar to octopamine, also strongly activated fat body phosphorylase, possibly by interaction with the octopamine receptor.
ISSN:0016-6480
1095-6840
DOI:10.1006/gcen.1997.7053