Severe pulmonary hypertension and amelioration of hepatopulmonary syndrome after liver transplantation

A patient with end‐stage liver disease as a result of α1‐antitripsin deficiency presented for orthotopic liver transplantation. The liver cirrhosis was complicated by portal hypertension and hepatopulmonary syndrome resulting in varicosities and severe hypoxia (room air oxygen saturation 69%). After...

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Bibliographic Details
Published in:Liver Transplantation and Surgery 1998-03, Vol.4 (2), p.177-179
Main Authors: Kaspar, Melanie D., Ramsay, Michael A.E., Shuey, Charles B., Levy, Marlon F., Klintmalm, Goran G.B.
Format: Article
Language:English
Subjects:
Adult
Dilatation, Pathologic - complications
Dilatation, Pathologic - surgery
Humans
Hypertension, Pulmonary - complications
Hypoxia - complications
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - surgery
Liver Transplantation - adverse effects
Male
Postoperative Complications
Pulmonary Artery - pathology
Pulmonary Veins - pathology
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Summary:A patient with end‐stage liver disease as a result of α1‐antitripsin deficiency presented for orthotopic liver transplantation. The liver cirrhosis was complicated by portal hypertension and hepatopulmonary syndrome resulting in varicosities and severe hypoxia (room air oxygen saturation 69%). After transplantation, the hepatopulmonary syndrome improved but, over the next 14 months, the patient developed severe pulmonary hypertension. Six years posttransplantation, his room air oxygen saturation was 95% with pulmonary artery pressures of 109 mm Hg systolic and 26 mm Hg diastolic (mean 55 mm Hg) and a pulmonary vascular resistance 688 dynes·sec·cm.5
ISSN:1074-3022
1527-6473
DOI:10.1002/lt.500040201