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Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty
The estrogen receptor (ER) protein is believed to play a role in the development and progression of breast cancer. In a previously published U.S. clinic-based study, a polymorphism in the ER gene (codon 325, CCC --> CCG) was found to be more common in 34 case subjects with a family history of bre...
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| Published in: | JNCI : Journal of the National Cancer Institute 1998-04, Vol.90 (7), p.532-536 |
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| container_end_page | 536 |
| container_issue | 7 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | SOUTHEY, M. C BATTEN, L. E MCCREDIE, M. R. E GILES, G. G DITE, G HOPPER, J. L VENTER, D. J |
| description | The estrogen receptor (ER) protein is believed to play a role in the development and progression of breast cancer. In a previously published U.S. clinic-based study, a polymorphism in the ER gene (codon 325, CCC --> CCG) was found to be more common in 34 case subjects with a family history of breast cancer than in 154 case subjects without such a history (mean allele frequencies +/- standard error = 0.28+/-0.05 versus 0.11+/-0.02; P |
| doi_str_mv | 10.1093/jnci/90.7.532 |
| format | article |
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Case subjects under the age of 40 years with a first primary breast cancer and control subjects, frequency-matched to the case subjects on the basis of age, and their relatives were interviewed to assess the family history of breast cancer. Polymorphism status of the ER gene was determined for 388 case subjects and 294 control subjects. All statistical tests were two-tailed.
There was no association between ER gene polymorphism status and breast cancer, before or after adjustment for risk factors. There was no difference in allele frequencies between case subjects and control subjects (0.232+/-0.015 versus 0.209+/-0.017; P = .4) or between women with and without a family history of breast cancer (P = .3), irrespective of case-control status. The findings were not altered when different definitions of family history of breast cancer were used and when allele frequencies were adjusted for residence and country of birth.
We found no evidence that the ER codon 325 polymorphism is associated with breast cancer before the age of 40 years or with a family history of breast cancer, despite ample power to detect effects half the magnitude of those previously reported.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/90.7.532</identifier><identifier>PMID: 9539249</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Alleles ; Australia ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Case-Control Studies ; Codon - genetics ; DNA Primers ; Estrogens ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical research ; Medical sciences ; Odds Ratio ; Polymorphism, Genetic ; Receptors, Estrogen - genetics ; Tumors ; Women</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1998-04, Vol.90 (7), p.532-536</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright Superintendent of Documents Apr 1, 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-f73b7bf63d42ba5124ef56876642461925e884f5529fb2f2f6fe003b69e181213</citedby><cites>FETCH-LOGICAL-c509t-f73b7bf63d42ba5124ef56876642461925e884f5529fb2f2f6fe003b69e181213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2201439$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9539249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SOUTHEY, M. C</creatorcontrib><creatorcontrib>BATTEN, L. E</creatorcontrib><creatorcontrib>MCCREDIE, M. R. E</creatorcontrib><creatorcontrib>GILES, G. G</creatorcontrib><creatorcontrib>DITE, G</creatorcontrib><creatorcontrib>HOPPER, J. L</creatorcontrib><creatorcontrib>VENTER, D. J</creatorcontrib><title>Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>The estrogen receptor (ER) protein is believed to play a role in the development and progression of breast cancer. In a previously published U.S. clinic-based study, a polymorphism in the ER gene (codon 325, CCC --> CCG) was found to be more common in 34 case subjects with a family history of breast cancer than in 154 case subjects without such a history (mean allele frequencies +/- standard error = 0.28+/-0.05 versus 0.11+/-0.02; P<.001). To determine whether this polymorphism is a risk factor for early-onset breast cancer, we conducted a population-based, case-control-family study in Australia.
Case subjects under the age of 40 years with a first primary breast cancer and control subjects, frequency-matched to the case subjects on the basis of age, and their relatives were interviewed to assess the family history of breast cancer. Polymorphism status of the ER gene was determined for 388 case subjects and 294 control subjects. All statistical tests were two-tailed.
There was no association between ER gene polymorphism status and breast cancer, before or after adjustment for risk factors. There was no difference in allele frequencies between case subjects and control subjects (0.232+/-0.015 versus 0.209+/-0.017; P = .4) or between women with and without a family history of breast cancer (P = .3), irrespective of case-control status. The findings were not altered when different definitions of family history of breast cancer were used and when allele frequencies were adjusted for residence and country of birth.
We found no evidence that the ER codon 325 polymorphism is associated with breast cancer before the age of 40 years or with a family history of breast cancer, despite ample power to detect effects half the magnitude of those previously reported.</description><subject>Adult</subject><subject>Alleles</subject><subject>Australia</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Case-Control Studies</subject><subject>Codon - genetics</subject><subject>DNA Primers</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Estrogen - genetics</subject><subject>Tumors</subject><subject>Women</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkUtLAzEURoMoWh9Ll0IQcTc170yWUuoDBDe6DpnpTZ06MxmTKdJ_b4qlCzeGQC58hxOSD6FLSqaUGH636uvmzpCpnkrODtCECkUKRok8RBNCmC7KUosTdJrSiuRlmDhGx0byPJgJsvM0xrCEHkeoYRhDxENoN12Iw0eTOuxGXIdF6DFnErt-gWOTPnHwuIrgUg5dX0PETY-_Q5ctFfgQAbsl4DyMm3N05F2b4GJ3nqH3h_nb7Kl4eX18nt2_FLUkZiy85pWuvOILwSonKRPgpSq1UoIJRQ2TUJbCS8mMr5hnXnkghFfKAC0po_wM3f56hxi-1pBG2zWphrZ1PYR1strokuX9L0gV15qrrfH6D7gK69jnR1jGiNkKdYaKX6iOIaUI3g6x6VzcWErsth67rccaYrXN9WT-aiddVx0s9vSuj5zf7HKXatf6mL-3SXssX0wFN_wHzCiWag</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>SOUTHEY, M. C</creator><creator>BATTEN, L. E</creator><creator>MCCREDIE, M. R. E</creator><creator>GILES, G. G</creator><creator>DITE, G</creator><creator>HOPPER, J. L</creator><creator>VENTER, D. J</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty</title><author>SOUTHEY, M. C ; BATTEN, L. E ; MCCREDIE, M. R. E ; GILES, G. G ; DITE, G ; HOPPER, J. L ; VENTER, D. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-f73b7bf63d42ba5124ef56876642461925e884f5529fb2f2f6fe003b69e181213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Australia</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Case-Control Studies</topic><topic>Codon - genetics</topic><topic>DNA Primers</topic><topic>Estrogens</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Estrogen - genetics</topic><topic>Tumors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SOUTHEY, M. C</creatorcontrib><creatorcontrib>BATTEN, L. E</creatorcontrib><creatorcontrib>MCCREDIE, M. R. E</creatorcontrib><creatorcontrib>GILES, G. G</creatorcontrib><creatorcontrib>DITE, G</creatorcontrib><creatorcontrib>HOPPER, J. L</creatorcontrib><creatorcontrib>VENTER, D. 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E</au><au>GILES, G. G</au><au>DITE, G</au><au>HOPPER, J. L</au><au>VENTER, D. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>90</volume><issue>7</issue><spage>532</spage><epage>536</epage><pages>532-536</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>The estrogen receptor (ER) protein is believed to play a role in the development and progression of breast cancer. In a previously published U.S. clinic-based study, a polymorphism in the ER gene (codon 325, CCC --> CCG) was found to be more common in 34 case subjects with a family history of breast cancer than in 154 case subjects without such a history (mean allele frequencies +/- standard error = 0.28+/-0.05 versus 0.11+/-0.02; P<.001). To determine whether this polymorphism is a risk factor for early-onset breast cancer, we conducted a population-based, case-control-family study in Australia.
Case subjects under the age of 40 years with a first primary breast cancer and control subjects, frequency-matched to the case subjects on the basis of age, and their relatives were interviewed to assess the family history of breast cancer. Polymorphism status of the ER gene was determined for 388 case subjects and 294 control subjects. All statistical tests were two-tailed.
There was no association between ER gene polymorphism status and breast cancer, before or after adjustment for risk factors. There was no difference in allele frequencies between case subjects and control subjects (0.232+/-0.015 versus 0.209+/-0.017; P = .4) or between women with and without a family history of breast cancer (P = .3), irrespective of case-control status. The findings were not altered when different definitions of family history of breast cancer were used and when allele frequencies were adjusted for residence and country of birth.
We found no evidence that the ER codon 325 polymorphism is associated with breast cancer before the age of 40 years or with a family history of breast cancer, despite ample power to detect effects half the magnitude of those previously reported.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>9539249</pmid><doi>10.1093/jnci/90.7.532</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1998-04, Vol.90 (7), p.532-536 |
| issn | 0027-8874 1460-2105 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Adult Alleles Australia Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Case-Control Studies Codon - genetics DNA Primers Estrogens Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical research Medical sciences Odds Ratio Polymorphism, Genetic Receptors, Estrogen - genetics Tumors Women |
| title | Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty |
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