Vasectomy and Non-Fatal Acute Myocardial Infarction: A Hospital-Based Case-Control Study in Seoul, Korea

• Published in: International journal of epidemiology 1990-03, Vol.19 (1), p.32-41
• Main Authors: CHI, I-CHENG, KO, UNG RING, WILKENS, LYNNE R, CHANG, HAN K, NAM, JUNG J
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; Epidemiologic Factors; Heart; Hospitals, University; Humans; Korea; Male; Medical sciences; Middle Aged; Myocardial Infarction - epidemiology; Myocardial Infarction - mortality; Population; Vasectomy
• ISSN: 0300-5771; 1464-3685
• DOI: 10.1093/ije/19.1.32

Chi IC (Family Health International, Research Triangle Park, NC 27709, USA), Wilkens LR, Ko UR, Chang HK and Nam JJ. Vasectomy and non-fatal acute myocardial infarction: A hospital-based case-control study in Seoul, Korea. International Journal of Epidemiology 1990, 19: 32–41. During 1983–1986, we conducted a hospital-based case-control study in the Republic of Korea to examine the possible relationship between vasectomy and cardiovascular morbidity in men. One hundred and sixty-three Korean men aged 35–64 who were admitted to a university-affiliated hospital diagnosed for the first time with acute myocardial infarction (AMI) were compared with 326 matched non-AMI patients hospitalized with a diagnosis considered unrelated to vasectomy. When other potentially confounding variables were controlled for, vasectomized men were found to be 2.6 times (adjusted odds ratio) more likely to have had an AMI as compared to the non-vasectomized men (95% CL: 1.1, 6.1). The adjusted odds ratio of AMI for subjects having had a vasectomy ≤9 years ago was the same as those who had a vasectomy ≥15 years (OR=2.5), although those who had had a vasectomy 10–14 years ago were associated with a higher odds ratio of 4.2. Among those subjects with vasectomies who were also cigarette-smokers and/or hypertensive, the risk of development of AMI increased multiplicatively compared with those with none of these conditions. We suspect that our finding of this positive association may be spurious due to possible bias introduced during selection of controls and during the process of data collection. Cancer patients may have been less likely to undergo an elective surgical procedure such as vasectomy prior to the admission. When multivariate analysis included only controls who were non-cancer patients (N=241 controls), the adjusted odds ratio between vasectomy and hospitalization for AMI was reduced to 2.1, (95% CL: 0.8, 5.7), which is no longer statistically significant. When the analysis was further limited to only those control subjects admitted with a diagnosis of digestive system problems, the adjusted odds ratio was reduced to close to unity (1.1). Recognizing the importance of the study topic and the fact that all previous epidemiological studies showed no association between vasectomy and cardiovascular diseases, we urge further studies. A historical cohort study in the Korean setting is considered feasible and is recommended.