Epidemiology of Systemic Candidiasis in a Tertiary Care Neonatal Unit

143 neonates were diagnosed to have acquired systemic candidiasis out of a total 4530 admissions (3.2 per cent) to the neonatal intensive care unit (NICU) during a period of 6½ years from January 1990 to June 1996. Mean age at onset was 10.4 days, mean birth weight 1454g, and mean gestation was 31.7...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1998-04, Vol.44 (2), p.104-108
Main Authors: Narang, Anil, Agrawal, Pankaj B., Chakrabarti, A., Kumar, Praveen
Format: Article
Language:English
Subjects:
Age of Onset
Bacteremia - diagnosis
Bacteremia - epidemiology
Bacteremia - microbiology
Biological and medical sciences
Candida
Candidiasis - diagnosis
Candidiasis - epidemiology
Candidiasis - microbiology
Cross Infection - diagnosis
Cross Infection - epidemiology
Cross Infection - microbiology
Female
Fungemia - diagnosis
Fungemia - epidemiology
Fungemia - microbiology
Human mycoses
Humans
Incidence
India - epidemiology
Infant, Newborn
Infectious diseases
Intensive Care Units, Neonatal - statistics & numerical data
Male
Medical sciences
Mycoses
Mycotic sepsis
Risk Factors
Survival Rate
Tropical medicine
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Summary:143 neonates were diagnosed to have acquired systemic candidiasis out of a total 4530 admissions (3.2 per cent) to the neonatal intensive care unit (NICU) during a period of 6½ years from January 1990 to June 1996. Mean age at onset was 10.4 days, mean birth weight 1454g, and mean gestation was 31.7 weeks. Ninety-four per cent were premature, 95 per cent low birth weight (LBW), and all had undergone peripheral vein catheterization and had received broad spectrum antibiotics, except one, prior to the diagnosis. Fifty-eight per cent were ventilated and 15 per cent received parenteral nutrition. Persistent/recurrent pneumonia, apnoea, lethargy, high gastric aspirates, and abdominal distension were the common clinical manifestations. Candida tropicalis, C. albicans, and C. guillermondii were the most common isolates. Blood and urine were the predominant sites for isolation of Candida. Fluconazole was the most used antifungal agent, with 24 per cent resistance against it. Fifty per cent of babies died due to all causes. Of all the deaths, two-thirds were Candida related. Candida-attributabie deaths occurred in 24 cases (17 per cent).
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/44.2.104