Plasma somatostatin-like immunoreactivity and somatostatin-28 levels in obese men

Somatostatin (SS) impairs nutrient absorption. It has been suggested that hyposomatostatinaemia may be involved in the pathogenesis of obesity. However, data on postprandial SS-like immunoreactivity (SLI) levels in obese subjects are controversial and the levels of SS-28, the main molecular form of...

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Bibliographic Details
Published in:Journal of endocrinological investigation 1998, Vol.21 (1), p.20-23
Main Authors: PERACCHI, M, CAROLA, F, CAVAGNINI, F, BENTI, R, BAREGGI, B, BACCALARO, G, BASILISCO, G
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Body Mass Index
Fasting
Food
Glucose Tolerance Test
Humans
Kinetics
Male
Medical sciences
Metabolic diseases
Obesity
Obesity - blood
Radioimmunoassay
Somatostatin - blood
Somatostatin-28
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Summary:Somatostatin (SS) impairs nutrient absorption. It has been suggested that hyposomatostatinaemia may be involved in the pathogenesis of obesity. However, data on postprandial SS-like immunoreactivity (SLI) levels in obese subjects are controversial and the levels of SS-28, the main molecular form of circulating SLI in healthy subjects, have not been determined. To characterise the fasting and postprandial plasma pattern of SLI and SS-28 in obese men, we studied eight obese men (age 24-32 yr, BMI 33-42 kg/m2), with normal glucose tolerance test and normal gastric emptying of solids, and eight healthy men (age 24-39 yr, BMI 21-24 kg/m2). Blood samples were taken at regular intervals in fasting conditions and for 2 h after a standard solid-liquid meal (2.3 MJ). Plasma SLI and SS-28 were measured by RIA. Our results showed that fasting and postprandial plasma SLI and SS-28 levels were not significantly different in healthy and obese subjects. In conclusion SS-28 is the predominant form of circulating SLI in obese subjects. The normal pattern of fasting and postprandial plasma SLI and SS-28 levels in such subjects suggests that somatostatin does not have a pathogenetic role in obesity.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03347281