Microdissection, microchip arrays, and molecular analysis of tumor cells (primary and metastases)

Advances in biotechnology and bioinformatics are offering promise for new breakthroughs in gene discovery and elucidation of gene function. At present, many candidate genes related to cancer pathogenesis have been identified in several types of human cancer, yet frequently their function remains elu...

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Bibliographic Details
Published in:Seminars in radiation oncology 1998-07, Vol.8 (3), p.217-223
Main Authors: Pappalardo, Philip A., Bonner, Robert, Krizman, David B., Emmert-Buck, Michael R., Liotta, Lance A.
Format: Article
Language:English
Subjects:
Base Sequence
Biotechnology
Disease Progression
Dissection
DNA, Neoplasm - analysis
DNA, Neoplasm - genetics
Gene Expression Regulation, Neoplastic - genetics
Humans
Medical Informatics Applications
Microchemistry - instrumentation
Microsurgery
Molecular Biology
Mutation - genetics
Neoplasm Metastasis - genetics
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - prevention & control
Neoplasms - therapy
Oncogenes - genetics
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Summary:Advances in biotechnology and bioinformatics are offering promise for new breakthroughs in gene discovery and elucidation of gene function. At present, many candidate genes related to cancer pathogenesis have been identified in several types of human cancer, yet frequently their function remains elusive. This is particularly true as it relates to the progression of human cancer. This landscape could change dramatically, however, as technological innovations and improvements continue to revolutionize these fields. High-throughput molecular approaches are emerging, which may become accurate, automated, and cost-effective. For example, DNA arrays on microchips are under development with numerous applications, including the ability to screen genes rapidly for mutations and to study patterns of gene expression on a large scale. Automated systems for microdissection and sequencing are also in their implementation stages. Commensurate with their integration and evolution, these information and technological tools have the potential to offer a more comprehensive understanding of multiple genetic and cellular alterations occurring during cancer initiation, development, and progression. Ultimately, this fundamental knowledge can provide strategies for intervention, prevention, and early diagnosis.
ISSN:1053-4296
1532-9461
DOI:10.1016/S1053-4296(98)80047-7