CD1-restricted T cells and resistance to polysaccharide-encapsulated bacteria

CD1 has been distinguished from conventional antigen-presenting molecules by its ability to present mycobacterial lipoglycans. Here, Rick Fairhurst and colleagues postulate that the hydrophobic groove of CD1 binds palmitic acid, displaying diverse, covalently-attached carbohydrates to T cells. Such...

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Bibliographic Details
Published in:Immunology today (Amsterdam. Regular ed.) 1998-06, Vol.19 (6), p.257-259
Main Authors: Fairhurst, Rick M, Wang, Chun-Xiang, Sieling, Peter A, Modlin, Robert L, Braun, Jonathan
Format: Article
Language:English
Subjects:
Animals
antigen presentation
Antigen Presentation - immunology
antigen recognition
Antigens, Bacterial - immunology
Antigens, CD1 - pharmacology
antimicrobal immunity
Bacterial Capsules - chemistry
Bacterial Capsules - immunology
CD1
gram-negative bacteria
Humans
Immunity, Innate - immunology
Mice
T-cell independent type 2 antigen
T-Lymphocytes - immunology
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Summary:CD1 has been distinguished from conventional antigen-presenting molecules by its ability to present mycobacterial lipoglycans. Here, Rick Fairhurst and colleagues postulate that the hydrophobic groove of CD1 binds palmitic acid, displaying diverse, covalently-attached carbohydrates to T cells. Such T cells may constitute a previously unappreciated subset that helps B cells mount an antibody response to polysaccharide antigens.
ISSN:0167-5699
DOI:10.1016/S0167-5699(97)01235-8