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Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial retinyl ester response to soybean oil
Background Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post‐prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests. Methods We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid c...
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| Published in: | European journal of clinical investigation 1998-05, Vol.28 (5), p.407-415 |
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| container_issue | 5 |
| container_start_page | 407 |
| container_title | European journal of clinical investigation |
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| creator | MERO, N SYVÄNNE, M ROSSENEU, M LABEUR, C HILDEN, H TASKINEN, M.-R |
| description | Background
Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post‐prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests.
Methods
We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid cream meal and a liquid soybean oil meal. The study group consisted of 10 healthy normolipidaemic men. We measured triglycerides (TGs), retinyl esters (REs), apolipoprotein E (apoE), apolipoprotein B‐48 (apoB‐48) and apolipoprotein B‐100 (apoB‐100) in plasma and in triglyceride‐rich lipoprotein (TRL) fractions separated by density‐gradient ultracentrifugation at baseline and 3, 4, 6, and 8 h after the FTTs.
Results
We observed similar TGs, apoE, apoB‐48 and apoB‐100 responses after all three FTTs, despite the different fatty acid composition of the meals. In contrast, the commonly used marker for exogenous particles, RE, differed clearly when polyunsaturated (soybean oil) and saturated fat (cream or mixed meal) were used. The RE response in plasma (P |
| doi_str_mv | 10.1046/j.1365-2362.1998.00309.x |
| format | article |
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Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post‐prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests.
Methods
We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid cream meal and a liquid soybean oil meal. The study group consisted of 10 healthy normolipidaemic men. We measured triglycerides (TGs), retinyl esters (REs), apolipoprotein E (apoE), apolipoprotein B‐48 (apoB‐48) and apolipoprotein B‐100 (apoB‐100) in plasma and in triglyceride‐rich lipoprotein (TRL) fractions separated by density‐gradient ultracentrifugation at baseline and 3, 4, 6, and 8 h after the FTTs.
Results
We observed similar TGs, apoE, apoB‐48 and apoB‐100 responses after all three FTTs, despite the different fatty acid composition of the meals. In contrast, the commonly used marker for exogenous particles, RE, differed clearly when polyunsaturated (soybean oil) and saturated fat (cream or mixed meal) were used. The RE response in plasma (P < 0.005, repeated measures
ANOVA), in chylomicrons (P < 0.013) and in very low‐density lipoprotein (VLDL) 1 (P < 0.017), as well as the RE area under the incremental curve in plasma and chylomicron fractions, were markedly increased after the soybean oil meal compared with the mixed meal and cream meal tests. The peak of RE response occurred parallel to the responses of other markers (i.e. TG or apoB‐48) of post‐prandial TRL during soybean oil meal. In contrast, RE peak concentration was delayed after saturated fat‐containing meals. After soybean oil, FTT plasma cholesterol concentration was lower and the chylomicron cholesterol concentration was higher compared with mixed or cream meals, but no differences were detected in post‐prandial high‐density lipoprotein (HDL)‐cholesterol concentration.
Conclusion
When the amount of fat is similar, post‐prandial responses of TG, apoE, apoB‐48, apoB‐100 and HDL‐cholesterol were comparable after different FTTs.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1046/j.1365-2362.1998.00309.x</identifier><identifier>PMID: 9650015</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Adult ; Apolipoprotein B-100 ; Apolipoprotein B-48 ; Apolipoproteins B - blood ; Apolipoproteins E - blood ; Biological and medical sciences ; Cholesterol - blood ; Dietary Fats - administration & dosage ; Dietary Fats - blood ; Fasting ; Functional investigation of endocrine glands and genital system ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lipids - blood ; Lipoproteins - metabolism ; Male ; Medical sciences ; polyunsaturated fatty acids ; post-prandial lipaemia ; Postprandial Period ; Retinol-Binding Proteins - metabolism ; Retinol-Binding Proteins, Plasma ; retinyl esters ; saturated fatty acids ; Soybean Oil - administration & dosage ; triglyceride-rich lipoproteins ; Triglycerides - blood</subject><ispartof>European journal of clinical investigation, 1998-05, Vol.28 (5), p.407-415</ispartof><rights>Blackwell Science Ltd, Oxford</rights><rights>1998 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. May 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5239-d937f38cfe3b0b1d453b67fad97f079fc2fec30681fe5ca7f813fe8af5b02db53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2250748$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9650015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MERO, N</creatorcontrib><creatorcontrib>SYVÄNNE, M</creatorcontrib><creatorcontrib>ROSSENEU, M</creatorcontrib><creatorcontrib>LABEUR, C</creatorcontrib><creatorcontrib>HILDEN, H</creatorcontrib><creatorcontrib>TASKINEN, M.-R</creatorcontrib><title>Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial retinyl ester response to soybean oil</title><title>European journal of clinical investigation</title><addtitle>European Journal of Clinical Investigation</addtitle><description>Background
Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post‐prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests.
Methods
We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid cream meal and a liquid soybean oil meal. The study group consisted of 10 healthy normolipidaemic men. We measured triglycerides (TGs), retinyl esters (REs), apolipoprotein E (apoE), apolipoprotein B‐48 (apoB‐48) and apolipoprotein B‐100 (apoB‐100) in plasma and in triglyceride‐rich lipoprotein (TRL) fractions separated by density‐gradient ultracentrifugation at baseline and 3, 4, 6, and 8 h after the FTTs.
Results
We observed similar TGs, apoE, apoB‐48 and apoB‐100 responses after all three FTTs, despite the different fatty acid composition of the meals. In contrast, the commonly used marker for exogenous particles, RE, differed clearly when polyunsaturated (soybean oil) and saturated fat (cream or mixed meal) were used. The RE response in plasma (P < 0.005, repeated measures
ANOVA), in chylomicrons (P < 0.013) and in very low‐density lipoprotein (VLDL) 1 (P < 0.017), as well as the RE area under the incremental curve in plasma and chylomicron fractions, were markedly increased after the soybean oil meal compared with the mixed meal and cream meal tests. The peak of RE response occurred parallel to the responses of other markers (i.e. TG or apoB‐48) of post‐prandial TRL during soybean oil meal. In contrast, RE peak concentration was delayed after saturated fat‐containing meals. After soybean oil, FTT plasma cholesterol concentration was lower and the chylomicron cholesterol concentration was higher compared with mixed or cream meals, but no differences were detected in post‐prandial high‐density lipoprotein (HDL)‐cholesterol concentration.
Conclusion
When the amount of fat is similar, post‐prandial responses of TG, apoE, apoB‐48, apoB‐100 and HDL‐cholesterol were comparable after different FTTs.</description><subject>Adult</subject><subject>Apolipoprotein B-100</subject><subject>Apolipoprotein B-48</subject><subject>Apolipoproteins B - blood</subject><subject>Apolipoproteins E - blood</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - blood</subject><subject>Fasting</subject><subject>Functional investigation of endocrine glands and genital system</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lipids - blood</subject><subject>Lipoproteins - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>polyunsaturated fatty acids</subject><subject>post-prandial lipaemia</subject><subject>Postprandial Period</subject><subject>Retinol-Binding Proteins - metabolism</subject><subject>Retinol-Binding Proteins, Plasma</subject><subject>retinyl esters</subject><subject>saturated fatty acids</subject><subject>Soybean Oil - administration & dosage</subject><subject>triglyceride-rich lipoproteins</subject><subject>Triglycerides - blood</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAUhS0EKkPLT0CyEGKX4Eccx4hNGfUlSqsKEOwsx7GJhyQOdkad_HscZjQLVqxs63zn3ut7AIAY5RgV5btNjmnJMkJLkmMhqhwhikS-ewJWR-EpWCGEi4wITp6DFzFuEEIVpuQEnIiSJY2twG7t-1EFF_0AvYVTG4yBVk3TDHujugjdANt0mdoZDj70vnOja5TpnU7A8B627mcLRx-nbAxqaJzqYDCTG-YOmjiZkF5x9EM0cPIw-rk2KnVy3Rl4ZlN98_JwnoJvlxdf19fZ7f3Vzfr8NtOMUJE1gnJLK20NrVGNm4LRuuRWNYJbxIXVxBpNUVlha5hW3KYPWlMpy2pEmprRU_B2X3cM_vc2jSR7F7XpOjUYv42SC8ELjBbw9T_gxm_DkGaTacOoFJgVCar2kA4-xmCsHIPrVZglRnJJRm7kEoBcAlh8lfybjNwl66tD_W3dm-ZoPESR9DcHXUWtOpu2qV08YoQwxIsqYR_22KPrzPzf7eXF-iZdkj3b210KZ3e0q_BLlpxyJr_fXclPXy7Jj4-fHySnfwBLu7qG</recordid><startdate>199805</startdate><enddate>199805</enddate><creator>MERO, N</creator><creator>SYVÄNNE, M</creator><creator>ROSSENEU, M</creator><creator>LABEUR, C</creator><creator>HILDEN, H</creator><creator>TASKINEN, M.-R</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199805</creationdate><title>Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial retinyl ester response to soybean oil</title><author>MERO, N ; SYVÄNNE, M ; ROSSENEU, M ; LABEUR, C ; HILDEN, H ; TASKINEN, M.-R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5239-d937f38cfe3b0b1d453b67fad97f079fc2fec30681fe5ca7f813fe8af5b02db53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Apolipoprotein B-100</topic><topic>Apolipoprotein B-48</topic><topic>Apolipoproteins B - blood</topic><topic>Apolipoproteins E - blood</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - blood</topic><topic>Fasting</topic><topic>Functional investigation of endocrine glands and genital system</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lipids - blood</topic><topic>Lipoproteins - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>polyunsaturated fatty acids</topic><topic>post-prandial lipaemia</topic><topic>Postprandial Period</topic><topic>Retinol-Binding Proteins - metabolism</topic><topic>Retinol-Binding Proteins, Plasma</topic><topic>retinyl esters</topic><topic>saturated fatty acids</topic><topic>Soybean Oil - administration & dosage</topic><topic>triglyceride-rich lipoproteins</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MERO, N</creatorcontrib><creatorcontrib>SYVÄNNE, M</creatorcontrib><creatorcontrib>ROSSENEU, M</creatorcontrib><creatorcontrib>LABEUR, C</creatorcontrib><creatorcontrib>HILDEN, H</creatorcontrib><creatorcontrib>TASKINEN, M.-R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MERO, N</au><au>SYVÄNNE, M</au><au>ROSSENEU, M</au><au>LABEUR, C</au><au>HILDEN, H</au><au>TASKINEN, M.-R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial retinyl ester response to soybean oil</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>European Journal of Clinical Investigation</addtitle><date>1998-05</date><risdate>1998</risdate><volume>28</volume><issue>5</issue><spage>407</spage><epage>415</epage><pages>407-415</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
Oral fat tolerance tests (FTTs) have been widely used as a tool to investigate post‐prandial lipaemia. However, there is no consensus regarding the type and amount of fat used in the tests.
Methods
We compared three commonly used FTTs, each containing 63 g of fat: a mixed meal, a liquid cream meal and a liquid soybean oil meal. The study group consisted of 10 healthy normolipidaemic men. We measured triglycerides (TGs), retinyl esters (REs), apolipoprotein E (apoE), apolipoprotein B‐48 (apoB‐48) and apolipoprotein B‐100 (apoB‐100) in plasma and in triglyceride‐rich lipoprotein (TRL) fractions separated by density‐gradient ultracentrifugation at baseline and 3, 4, 6, and 8 h after the FTTs.
Results
We observed similar TGs, apoE, apoB‐48 and apoB‐100 responses after all three FTTs, despite the different fatty acid composition of the meals. In contrast, the commonly used marker for exogenous particles, RE, differed clearly when polyunsaturated (soybean oil) and saturated fat (cream or mixed meal) were used. The RE response in plasma (P < 0.005, repeated measures
ANOVA), in chylomicrons (P < 0.013) and in very low‐density lipoprotein (VLDL) 1 (P < 0.017), as well as the RE area under the incremental curve in plasma and chylomicron fractions, were markedly increased after the soybean oil meal compared with the mixed meal and cream meal tests. The peak of RE response occurred parallel to the responses of other markers (i.e. TG or apoB‐48) of post‐prandial TRL during soybean oil meal. In contrast, RE peak concentration was delayed after saturated fat‐containing meals. After soybean oil, FTT plasma cholesterol concentration was lower and the chylomicron cholesterol concentration was higher compared with mixed or cream meals, but no differences were detected in post‐prandial high‐density lipoprotein (HDL)‐cholesterol concentration.
Conclusion
When the amount of fat is similar, post‐prandial responses of TG, apoE, apoB‐48, apoB‐100 and HDL‐cholesterol were comparable after different FTTs.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>9650015</pmid><doi>10.1046/j.1365-2362.1998.00309.x</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0014-2972 |
| ispartof | European journal of clinical investigation, 1998-05, Vol.28 (5), p.407-415 |
| issn | 0014-2972 1365-2362 |
| language | eng |
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| source | Wiley |
| subjects | Adult Apolipoprotein B-100 Apolipoprotein B-48 Apolipoproteins B - blood Apolipoproteins E - blood Biological and medical sciences Cholesterol - blood Dietary Fats - administration & dosage Dietary Fats - blood Fasting Functional investigation of endocrine glands and genital system Humans Investigative techniques, diagnostic techniques (general aspects) Lipids - blood Lipoproteins - metabolism Male Medical sciences polyunsaturated fatty acids post-prandial lipaemia Postprandial Period Retinol-Binding Proteins - metabolism Retinol-Binding Proteins, Plasma retinyl esters saturated fatty acids Soybean Oil - administration & dosage triglyceride-rich lipoproteins Triglycerides - blood |
| title | Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial retinyl ester response to soybean oil |
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