Necrotizing fasciitis caused by Vibrio vulnificus differs from that caused by streptococcal infection

• Published in: The Journal of infection 1998-05, Vol.36 (3), p.313-316
• Main Authors: Fujisawa, N., Yamada, H., Kohda, H., Tadano, J., Hayashi, S.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Bacterial diseases; Bacterial diseases of the nervous system. Bacterial myositis; Biological and medical sciences; Child; Fasciitis, Necrotizing - etiology; Fasciitis, Necrotizing - microbiology; Female; Human bacterial diseases; Humans; Infectious diseases; Japan; Male; Medical sciences; Middle Aged; Seasons; Streptococcal Infections - complications; Streptococcus pyogenes; Vibrio; Vibrio Infections - complications; Vibrio vulnificus
• ISSN: 0163-4453; 1532-2742
• DOI: 10.1016/S0163-4453(98)94387-0

We reviewed the clinical record of all patients admitted to Saga Medical School Hospital during the most recent 10 years and found that 17 (0.03%) were diagnosed as having necrotizing fasciitis. Bacteriological examination demonstrated that Vibrio vulnificus was the pathogen responsible in five patients (29%). The disease caused by V. vulnificus occurred in the warmer half of the year. All of the patients had underlying chronic liver dysfunction, and three of them had previously consumed raw seafood. In these patients, the predominant skin lesions were oedema and subcutaneous bleeding, such as ecchymosis and purpura, while superficial necrosis was not recognized. Three patients died of systemic complications. By contrast, all of the five patients with necrotizing fasciitis caused by Streptococcus pyogenes had the disorder in winter, and only one of them had chronic liver dysfunction. In skin lesions, subcutaneous bleeding was rare but necrosis was seen often. Despite the high incidence of systemic complications, no patients with streptococcal necrotizing fasciitis died. These findings suggest that the clinical features of necrotizing fasciitis caused by V. vulnificus are different from those of necrotizing fasciitis caused by classical pathogens, and that the two should be differentiated as early as possible to improve the prognosis.