The neurotransmitter role of diadenosine polyphosphates

Diadenosine polyphosphates present at the cytosol can be transported to secretory granules allowing their exocytotic release. Extracellularly, they can act through specific metabotropic or ionotropic receptors, or as analogues of P2X and P2Y nucleotide receptors. The specific ionotropic receptor P4...

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Bibliographic Details
Published in:FEBS Letters 1998-06, Vol.430 (1), p.78-82
Main Authors: Miras-Portugal, M.Teresa, Gualix, Javier, Pintor, Jesús
Format: Article
Language:English
Subjects:
Adenine dinucleotide
Adenosine
Animals
Ap nA
ApnA
Cytoplasm - metabolism
Dinucleoside Phosphates - physiology
Extracellular Space - metabolism
Neurotransmitter Agents - physiology
Nucleotide receptor
Protein kinase
Protein phosphatase
Purinergic receptor
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Summary:Diadenosine polyphosphates present at the cytosol can be transported to secretory granules allowing their exocytotic release. Extracellularly, they can act through specific metabotropic or ionotropic receptors, or as analogues of P2X and P2Y nucleotide receptors. The specific ionotropic receptor P4 is present in synaptic terminals, and modulated by protein kinases (PK) A and C and protein phosphatases. Activation of PKA or PKC, directly or through membrane receptors, results in a decrease of affinity or in reduction of the Ca 2+ transient respectively. Adenosine and ATP, both products of the extracellular destruction of diadenosine polyphosphates, acting through A 1 or P2Y receptors respectively, are important physiological modulators at the P4 receptor.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)00560-2