Selective Serotonin Reuptake Inhibitors May Enhance Responses to Noxious Stimulation

The acute effects of various doses of two selective serotonin reuptake inhibitors (fluoxetine and fluvoxamine) on thermal and electrical stimulation-induced pain were investigated in drug-naive Wistar rats. The hot-plate and the tail-flick test and the noxious-induced withdrawal test were used. The...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-07, Vol.60 (3), p.719-725
Main Authors: Dirksen, R., Van Luijtelaar, E.L.J.M., Van Rijn, C.M.
Format: Article
Language:English
Subjects:
Analgesics
Animals
Biological and medical sciences
Blood Pressure - drug effects
Dose-Response Relationship, Drug
Electric Stimulation
Fluoxetine
Fluoxetine - pharmacology
Fluvoxamine
Fluvoxamine - pharmacology
Heart Rate - drug effects
Hot Temperature - adverse effects
Male
Medical sciences
Neuropharmacology
Nociception
Noxious-induced withdrawal reflex
Pain - psychology
Pain Measurement - drug effects
Pharmacology. Drug treatments
Rats
Rats, Wistar
Reaction Time - drug effects
serotonin uptake inhibitors
Serotonin Uptake Inhibitors - pharmacology
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Summary:The acute effects of various doses of two selective serotonin reuptake inhibitors (fluoxetine and fluvoxamine) on thermal and electrical stimulation-induced pain were investigated in drug-naive Wistar rats. The hot-plate and the tail-flick test and the noxious-induced withdrawal test were used. The two drugs had no effects on heat-induced pain behavior. However, the two compounds enhanced the motor responses induced by noxious electrical stimulation. These data contrast to what is generally found for tricyclic antidepressants and suggest a modality specific pain system. Cardiac and blood pressure were also found to change, but these changes were not correlated to changes in nociception. Taken together, the data suggest that the acutely administered selective serotonin reuptake inhibitors may exacerbate an acute type of pain.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(98)00030-6