Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD‐associated heartburn and the occurrence of underlying oesophagitis

Background: There is documentation of the long‐term use of omeprazole 10 mg o.d. in patients with reflux oesophagitis but not in the large number of gastro‐oesophageal reflux disease (GERD) patients without oesophagitis. There is also a paucity of data on the long‐term use of cimetidine in GERD pati...

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Published in:Alimentary pharmacology & therapeutics 1998-01, Vol.12 (1), p.41-47
Main Authors: BATE, C. M, GREEN, J. R. B, AXON, A. T. R, TILDESLEY, G, MURRAY, F. E, OWEN, S. M, EMMAS, C, TAYLOR, M. D
Format: Article
Language:English
Subjects:
Administration, Oral
Anti-Ulcer Agents - administration & dosage
Anti-Ulcer Agents - therapeutic use
Biological and medical sciences
Chi-Square Distribution
Cimetidine - administration & dosage
Cimetidine - therapeutic use
Digestive system
Double-Blind Method
Esophagitis - etiology
Esophagitis - prevention & control
Female
Gastroesophageal Reflux - complications
Gastroesophageal Reflux - drug therapy
Heartburn - etiology
Heartburn - prevention & control
Histamine H2 Antagonists - administration & dosage
Histamine H2 Antagonists - therapeutic use
Humans
Male
Medical sciences
Omeprazole - administration & dosage
Omeprazole - therapeutic use
Pharmacology. Drug treatments
Secondary Prevention
Treatment Outcome
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Summary:Background: There is documentation of the long‐term use of omeprazole 10 mg o.d. in patients with reflux oesophagitis but not in the large number of gastro‐oesophageal reflux disease (GERD) patients without oesophagitis. There is also a paucity of data on the long‐term use of cimetidine in GERD patients. Methods: One hundred and fifty‐six patients (100 male) who previously had symptomatic non‐ulcerative oesophagitis (81%) or symptoms without oesophagitis (19%), were recruited. All patients were in symptomatic remission following 4 weeks of omeprazole 20 mg o.d. or cimetidine 400 mg q.d.s. and, if required, a further 4 weeks of omeprazole 20 mg o.d. Patients were randomized to receive, double‐blind, either omeprazole 10 mg o.m. (n = 77) or cimetidine 800 mg nocte (n = 79) for 24 weeks. Results: A greater proportion of patients receiving omeprazole, compared with cimetidine, were in symptomatic remission after 12 (69 vs. 27%) and 24 weeks (60 vs. 24%) (each P 
ISSN:0269-2813
1365-2036
DOI:10.1046/j.1365-2036.1998.00272.x