Influence of mixing method on the cement temperature-mixing time history and doughing time of three acrylic cements for vertebroplasty

• Published in: Journal of biomedical materials research 2004-01, Vol.68B (1), p.112-116
• Main Authors: Baroud, G., Samara, M., Steffen, T.
• Format: Article
• Language: English
• Subjects: acrylic bone cements; Bone Substitutes - chemical synthesis; Bone Substitutes - chemistry; manual mixing; manual mixing, oscillatory mixing, temperature–mixing time history; oscillatory mixing; Polymethyl Methacrylate - chemical synthesis; Polymethyl Methacrylate - chemistry; Spine - surgery; Temperature; temperature-mixing time history; Time Factors; vertebroplasty
• ISSN: 1552-4973; 0021-9304; 1552-4981
• DOI: 10.1002/jbm.b.20009

Acrylic cements are increasingly being used to augment osteoporotic vertebrae in a procedure called vertebroplasty. Two significant factors that may complicate the use of acrylic cements are: (a) short handling time, which may result in insufficient filling of the vertebra; and (b) exothermic setting (curing) behavior, which may result in thermal damage of the surrounding tissue. It has been previously reported1 that mixing the cement components under oscillation, as compared to manual mixing, increases the handling time. More specifically, it seems that oscillatory mixing slows down the cement polymerization process and, consequently, widens the time window during which cement is injectable. However, the effect of oscillatory mixing on the exothermic setting behavior of cement undergoing polymerization has not been examined. In this study, the exothermic setting behavior of three commercially available acrylic cements— Antibiotic Simplex®, DP‐Pour&trade, and Vertebroplastic™—were examined for both manual and oscillatory mixing methods. For each combination of cement and mixing method, the parameters that were measured were the exothermic setting curve (and hence the cement setting temperature and setting time) and the cement doughing time. It was found that oscillatory mixing had no significant effect on any of these parameters. Based on the results of this study, it can be concluded that, for the tested cements, the setting process is a reaction‐controlled process rather than a diffusion‐controlled one. Clinically, this implies that oscillatory mixing may be used to increase the working period for acrylic cements without increasing the risk of thermal damage to surrounding tissue. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 68B: 112–116, 2004