Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak VO2 with Small Muscle Mass Exercise

• Published in: American journal of respiratory and critical care medicine 2004-01, Vol.169 (1), p.89-96
• Main Authors: Richardson, Russell S, Leek, Bryan T, Gavin, Timothy P, Haseler, Luke J, Mudaliar, Sundar R. D, Henry, Robert, Mathieu-Costello, Odile, Wagner, Peter D
• Format: Article
• Language: English
• Subjects: Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Gas Analysis; Case-Control Studies; Exercise Test - methods; Exercise Tolerance - physiology; Female; Humans; Intensive care medicine; Male; Medical sciences; Middle Aged; Muscle, Skeletal - pathology; Muscle, Skeletal - physiology; Oxygen Consumption - physiology; Probability; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Gas Exchange; Reference Values; Respiratory Function Tests; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index
• ISSN: 1073-449X; 1535-4970
• DOI: 10.1164/rccm.200305-627OC

We studied six patients with chronic obstructive pulmonary disease (COPD) (FEV1 = 1.1 +/- 0.2 L, 32% of predicted) and six age- and activity level-matched control subjects while performing both maximal bicycle exercise and single leg knee-extensor exercise. Arterial and femoral venous blood sampling, thermodilution blood flow measurements, and needle biopsies allowed the assessment of muscle oxygen supply, utilization, and structure. Maximal work rates and single leg VO2max (control subjects = 0.63 +/- 0.1; patients with COPD = 0.37 +/- 0.1 L/minute) were significantly greater in the control group during bicycle exercise. During knee-extensor exercise this difference in VO2max disappeared, whereas maximal work capacity was reduced (flywheel resistance: control subjects = 923 +/- 198; patients with COPD = 612 +/- 81 g) revealing a significantly reduced mechanical efficiency (work per unit oxygen consumed) with COPD. The patients had an elevated number of less efficient type II muscle fibers, whereas muscle fiber cross-sectional areas, capillarity, and mitochondrial volume density were not different between the groups. Therefore, although metabolic capacity per se is unchanged, fiber type differences associated with COPD may account for the reduced muscular mechanical efficiency that becomes clearly apparent during knee-extensor exercise, when muscle function is no longer overshadowed by the decrement in lung function.