Association between fasting glucose and C-reactive protein in middle-aged subjects

• Published in: Diabetic medicine 2004-01, Vol.21 (1), p.39-44
• Main Authors: Aronson, D., Bartha, P., Zinder, O., Kerner, A., Shitman, E., Markiewicz, W., Brook, G. J., Levy, Y.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Blood Glucose - analysis; Body Mass Index; C-reactive protein; C-Reactive Protein - analysis; Cholesterol, HDL - blood; Cross-Sectional Studies; Diabetes Mellitus - blood; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Fasting - blood; Female; glucose; Hormone Replacement Therapy; Humans; inflammation; insulin resistance syndrome; Male; Medical sciences; Metabolic Syndrome - blood; Middle Aged; obesity; Smoking; Uric Acid - blood
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1046/j.1464-5491.2003.01084.x

Aims  C‐reactive protein (CRP), a marker of subclinical inflammation, predicts the occurrence of coronary heart disease in healthy subjects. Hyperglycaemia is known to stimulate the release of inflammatory cytokines from various cell types and can lead to the induction and secretion of acute‐phase reactants by adipocytes. The aim of the present study was to determine the relation between glycaemic status and CRP in healthy subjects. Methods  We studied the relation of high‐sensitivity CRP to fasting glucose and other components of the metabolic syndrome in a population‐based cross‐sectional study (n = 1000; age 50 ± 9 years). Results  Plasma CRP levels increased continuously from the lowest quartile of normal fasting glucose level to impaired fasting glucose and to diabetes (ln CRP 0.47 ± 0.09, 0.95 ± 0.12, and 1.11 ± 0.13, respectively; Ptrend