CEREBROSPINAL FLUID TRANSFER OF CEFBUPERAZONE IN THE BLOOD-BRAIN BARRIER LESIONS OF NEUROSURGICAL PATIENTS

Cefbuperazone (CBPZ) was given in 15 patients after surgery. There was no infections except for 1 case in which signs of infections were suspected. As side effects, slight elevations in hepatic transaminase levels were observed in 3 patients during the CBPZ chemotherapy. CBPZ concentrations in 7 pat...

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Published in:Japanese journal of antibiotics 1990/06/25, Vol.43(6), pp.1174-1180
Main Authors: NAKATA, MUNETOMO, MUKAWA, JIRO, MIYAGI, KOUICHI, KINJOU, TOSHIHIKO, SAKUTA, OSAMU, MIYAZATO, HIROSHI, OKUYAMA, KUNIO, HIGA, YASUSHI, TERADA, YUKITOSHI
Format: Article
Language:Japanese
Subjects:
Adolescent
Adult
Aged
Bacterial Infections - prevention & control
Blood-Brain Barrier
Brain Diseases - cerebrospinal fluid
Brain Diseases - surgery
Cephamycins - cerebrospinal fluid
Cephamycins - therapeutic use
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Postoperative Complications - prevention & control
Premedication
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container_end_page 1180
container_issue 6
container_start_page 1174
container_title Japanese journal of antibiotics
container_volume 43
creator NAKATA, MUNETOMO
MUKAWA, JIRO
MIYAGI, KOUICHI
KINJOU, TOSHIHIKO
SAKUTA, OSAMU
MIYAZATO, HIROSHI
OKUYAMA, KUNIO
HIGA, YASUSHI
TERADA, YUKITOSHI
description Cefbuperazone (CBPZ) was given in 15 patients after surgery. There was no infections except for 1 case in which signs of infections were suspected. As side effects, slight elevations in hepatic transaminase levels were observed in 3 patients during the CBPZ chemotherapy. CBPZ concentrations in 7 patients were studied. The subjects were divided into 3 groups according to CT findings during the chemotherapy to correlate CBPZ concentrations to degrees of blood-brain barrier lesions; Group I: no enhancement, Group II: mild or focal enhancement, Group III: diffuse and marked enhancement. It was interesting to note that the more marked enhancement were obtained, the higher levels of CSF concentration of CBPZ.
doi_str_mv 10.11553/antibiotics1968b.43.1174
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identifier ISSN: 0368-2781
ispartof The Japanese Journal of Antibiotics, 1990/06/25, Vol.43(6), pp.1174-1180
issn 0368-2781
2186-5477
language jpn
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source Alma/SFX Local Collection
subjects Adolescent
Adult
Aged
Bacterial Infections - prevention & control
Blood-Brain Barrier
Brain Diseases - cerebrospinal fluid
Brain Diseases - surgery
Cephamycins - cerebrospinal fluid
Cephamycins - therapeutic use
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Postoperative Complications - prevention & control
Premedication
title CEREBROSPINAL FLUID TRANSFER OF CEFBUPERAZONE IN THE BLOOD-BRAIN BARRIER LESIONS OF NEUROSURGICAL PATIENTS
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