Long-term fracture risk following renal transplantation: a population-based study

Abnormal bone metabolism is a recognized complication of end-stage renal disease, but fracture risk following renal transplantation has not been well quantified. We followed the 86 Olmsted County, Minnesota, residents who underwent initial renal transplantation in 1965-1995 for 911 person-years (med...

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Bibliographic Details
Published in:Osteoporosis international 2004-02, Vol.15 (2), p.160-167
Main Authors: Vautour, Line M, Melton, 3rd, L Joseph, Clarke, Bart L, Achenbach, Sara J, Oberg, Ann L, McCarthy, James T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Child, Preschool
Diabetes
Diabetic Nephropathies - complications
Diabetic Nephropathies - surgery
Epidemiologic Methods
Epidemiology
Female
Fractures
Fractures, Bone - epidemiology
Fractures, Bone - etiology
Health sciences
Humans
Immunosuppressive agents
Incidence
Internal medicine
Kidney diseases
Kidney Transplantation - adverse effects
Kidney transplants
Male
Medical prognosis
Medical records
Medical schools
Medicine
Metabolism
Middle Aged
Minnesota - epidemiology
Osteoporosis
Osteoporosis - etiology
Risk factors
Steroids
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Summary:Abnormal bone metabolism is a recognized complication of end-stage renal disease, but fracture risk following renal transplantation has not been well quantified. We followed the 86 Olmsted County, Minnesota, residents who underwent initial renal transplantation in 1965-1995 for 911 person-years (median, 10.6 years per subject) in a retrospective cohort study. Fractures, and possible risk factors, were assessed through review of each subject's complete community medical records. Altogether, 117 fractures were observed during follow-up extending to 33 years. The cumulative incidence of any fracture at 15 years was 60% versus 20% expected ( P
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-003-1532-y