Persistent Remodeling of Resistance Arteries in Type 2 Diabetic Patients on Antihypertensive Treatment

ABSTRACT—We hypothesized that resistance arteries from diabetic patients with controlled hypertension have less remodeling than vessels from untreated hypertensive subjects. Eight normotensive subjects (aged 44±3 years, 3 men; values are mean±SEM), 19 untreated hypertensive subjects (46±2 years, 9 m...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-02, Vol.43 (2, Part 2), p.399-404
Main Authors: Endemann, Dierk H, Pu, Qian, De Ciuceis, Carolina, Savoia, Carmine, Virdis, Agostino, Neves, Mario F, Touyz, Rhian M, Schiffrin, Ernesto L
Format: Article
Language:English
Subjects:
Adult
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive agents
Antihypertensive Agents - therapeutic use
Arterial hypertension. Arterial hypotension
Arteries - pathology
Arteries - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diabetes Mellitus, Type 2 - complications
Female
Humans
Hypertension - complications
Hypertension - drug therapy
Hypertension - pathology
Hypertension - physiopathology
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Vascular Resistance
Vasodilation
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Summary:ABSTRACT—We hypothesized that resistance arteries from diabetic patients with controlled hypertension have less remodeling than vessels from untreated hypertensive subjects. Eight normotensive subjects (aged 44±3 years, 3 men; values are mean±SEM), 19 untreated hypertensive subjects (46±2 years, 9 men), and 23 hypertensive subjects with type 2 diabetes mellitus under antihypertensive treatment (58±1 years, 15 men) were studied. Resistance arteries dissected from gluteal subcutaneous tissue were assessed on a pressurized myograph. Most diabetic patients (70%) were being treated with angiotensin-converting enzyme inhibitors. Although systolic blood pressure was still above the normotensive range in these patients (144±2 versus 150±3 mm Hg in hypertensive and 114±4 mm Hg in normotensive subjects), diastolic blood pressure was well controlled (83±2 mm Hg) and significantly lower compared with that in untreated hypertensives (100±1 mm Hg; P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000112029.03691.e7