Eosinophil function in allergic inflammation: from bone marrow to tissue response

The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the past two decades. Although the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in human and animal tissue response is...

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Bibliographic Details
Published in:Current allergy and asthma reports 2004-03, Vol.4 (2), p.149-158
Main Authors: Adamko, Darryl, Lacy, Paige, Moqbel, Redwan
Format: Article
Language:English
Subjects:
Animals
Asthma
Bone Marrow - physiopathology
Cell Degranulation - physiology
Cell Movement - physiology
Cell Survival - physiology
Chemokines - metabolism
Eosinophilia - metabolism
Eosinophilia - physiopathology
Eosinophils - cytology
Eosinophils - metabolism
Eosinophils - physiology
Humans
Hypersensitivity - metabolism
Hypersensitivity - physiopathology
Inflammation - metabolism
Inflammation - physiopathology
Respiratory Hypersensitivity - metabolism
Respiratory Hypersensitivity - physiopathology
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Summary:The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the past two decades. Although the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in human and animal tissue response is still unclear. However, recent developments in research on many organ systems have provided novel insights into the possible underlying role of the eosinophil in both allergic and nonallergic inflammation. In this review, we examine the pathways associated with eosinophil recruitment and activation, and discuss these findings with reference to clinically defined categories.
ISSN:1529-7322
1534-6315
DOI:10.1007/s11882-004-0061-x